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CAS 100-46-9
phenylmethanamine1-Phenylmethylamine
Codes: LACO-006, (XIII)638294-2-a, (IX)638294-13-a, (IV)101438-34-a, (II)109067-9-a, VARE-017
Application context (from source-drug indications)
Tonic-clonic seizureLacosamideEpilepsyLacosamidePartial-onset seizureLacosamideSeizureLacosamideSystolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneBreast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateHypertensionOlmesartan Medoxomil/Amlodipine orotateEssential hypertensionValsartan/Amlodipine OrotateNicotine dependenceVarenicline TartrateNicotine withdrawalVarenicline TartrateSmoking cessationVarenicline TartrateSmoking reductionVarenicline TartrateCannabis dependenceVarenicline TartrateNebulisationVarenicline TartrateVariant anginaAmlodipine OrotateHypertensionAmlodipine OrotateIschaemic heart diseaseAmlodipine OrotateStable anginaAmlodipine OrotatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelHypertensionAmlodipine Camsylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lacosamide | Tier B — Position early | 2028 |
| Finerenone | Tier C — Watch / trade | 2030 |
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Olmesartan Medoxomil/Amlodipine orotate | Tier C — Watch / trade | - |
| Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
| Varenicline Tartrate | Tier B — Position early | - |
| Amlodipine Orotate | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
| Amlodipine Camsylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
phenylmethanamine→N-acetyl-O-methyl-D-serine→methyl D-serinate→diethoxytriphenyl-l5-phosphane→ethyl (R)-aziridine-2-carboxylate→methyl (R)-aziridine-2-carboxylate→ethyl (R)-1-acetylaziridine-2-carboxylate→methyl (R)-1-acetylaziridine-2-carboxylate→ethyl N-acetyl-O-methyl-D-serinate→methyl N-acetyl-O-methyl-D-serinate→4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride→triphenylphosphane→sodium ethanolate
4-Bromo-2-hydroxybenzoic acid→2-Methoxy-4-bromobenzoic acid methyl ester→4-Bromo-2-methoxybenzaldehyde→2-Methoxy-4-cyanobenzaldehyde→3-Oxobutanamide→(2E)-2-[(4-Cyano-2-methoxyphenyl)methylidene]-3-oxobutanamide→(2Z)-2-[(4-Cyano-2-methoxyphenyl)methylidene]-3-oxobutanamide→4-Amino-5-methylpyridin-2(1H)-one→4-(4-Cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxamide→1,1,1-Triethoxyethane→(±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→2,4-Dihydroxy-5-methylpyridine→1-Phenylmethylamine→4-(Benzylamino)-5-methylpyridin-2(1H)-one
2-Methoxy-4-cyanobenzaldehyde→N-(4-Methoxybenzyl)acetoacetamide→3-Oxo-N-(phenylmethyl)butanamide→2-[(4-Cyano-2-methoxyphenyl)methylidene]-N-[(4-methoxyphenyl)methyl]-3-oxobutanamide→N-Benzyl-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanamide→4-Amino-5-methylpyridin-2(1H)-one→4-(4-Cyano-2-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxamide→N-Benzyl-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxamide→(Diethoxymethoxy)ethane→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-N-[(4-methoxyphenyl)methyl]-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→N-Benzyl-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→1-Phenylmethylamine→(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-N-[(4-methoxyphenyl)methyl]-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→(4S)-N-Benzyl-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
(+)-Diethyl L-tartrate→(2S,3S)-3-(benzyloxy)butane-1,2,4-triol→(2S)-2-(benzyloxy)-3-hydroxypropanal→1-Phenylmethylamine→methyl (2R,3S)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropanoate→(2R,3Z)-3-(benzylimino)-2-(benzyloxy)propan-1-ol→(2R,3R)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropan-1-ol→(2R,3S)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropan-1-ol→(2R,3S)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropanoic acid→(2R,3S)-3-Phenylisoserine methyl ester→methyl (2R,3S)-3-amino-3-phenyl-2-[(triethylsilyl)oxy]propanoate→(3R,4S)-4-Phenyl-3-[(triethylsilyl)oxy]azetidin-2-one→(3R,4S)-1-Benzoyl-4-phenyl-3-(triethylsiloxy)azetidin-2-one
2-Butynoic acid methyl ester→1-Phenylmethylamine→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-azidoethan-1-ol→3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate
2-Butynoic acid methyl ester→1-Phenylmethylamine→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-azidoethan-1-ol→3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate
2-Butynoic acid methyl ester→1-Phenylmethylamine→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-azidoethan-1-ol→3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(+)-Diethyl L-tartrate→(2S,3S)-3-(benzyloxy)butane-1,2,4-triol→(2S)-2-(benzyloxy)-3-hydroxypropanal→1-Phenylmethylamine→methyl (2R,3S)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropanoate→(2R,3Z)-3-(benzylimino)-2-(benzyloxy)propan-1-ol→(2R,3R)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropan-1-ol→(2R,3S)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropan-1-ol→(2R,3S)-3-(benzylamino)-2-(benzyloxy)-3-phenylpropanoic acid→(2R,3S)-3-Phenylisoserine methyl ester→methyl (2R,3S)-3-amino-3-phenyl-2-[(triethylsilyl)oxy]propanoate→(3R,4S)-4-Phenyl-3-[(triethylsilyl)oxy]azetidin-2-one→(3R,4S)-1-Benzoyl-4-phenyl-3-(triethylsiloxy)azetidin-2-one
2-Butynoic acid methyl ester→1-Phenylmethylamine→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-azidoethan-1-ol→3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1,4-DIHYDRO-1,4-METHANONAPHTHALENE Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2,3,4,5-Tetrahydro-7,8-dinitro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2,3,4,5-Tetrahydro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine-7,8-diamine Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.