CAS 124-40-3

dimethylamineN-MethylmethanamineDimethylamineDimethylamine anhydrous

Codes: RIBO-007, Tetracaine-021, SUMAT-007, DESV-002, Desvenlafaxine-012, (XIV)145089-2-a, (XI)145089-4-b, (IV)145089-11-a, (III)145089-21-a

Application context (from source-drug indications)

Breast cancerRibociclib SuccinateAnaesthesiaOxymetazoline Hydrochloride/Tetracaine HydrochloridePeriapical periodontitisOxymetazoline Hydrochloride/Tetracaine HydrochlorideDental cariesOxymetazoline Hydrochloride/Tetracaine HydrochlorideMigraineNaproxen Sodium/Sumatriptan SuccinateMigraine without auraNaproxen Sodium/Sumatriptan SuccinateDepressive disorderDesvenlafaxine Succinate HydrateMajor depressive disorderDesvenlafaxine Succinate HydrateDepressionDesvenlafaxine Succinate HydrateDiabetic neuropathyDesvenlafaxine Succinate HydratePainDesvenlafaxine Succinate HydrateFibromyalgiaDesvenlafaxine Succinate HydrateMajor depressive disorderDesvenlafaxineDepressive disorderDesvenlafaxineAnaesthesiaTetracaine HydrochlorideRetinitis pigmentosaTetracaine HydrochloridePainTetracaine HydrochlorideCluster headacheSumatriptan SuccinateMigraineSumatriptan SuccinateSecondary headache disorderSumatriptan SuccinatePost-traumatic headacheSumatriptan SuccinateAlzheimer's diseaseRivastigmine TartrateDementiaRivastigmine TartrateParkinson's diseaseRivastigmine Tartrate抗胆碱能综合征Rivastigmine Tartrate神经行为学表现Rivastigmine TartrateCognitive impairmentRivastigmine Tartrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Ribociclib Succinate	Tier A — Act now	2029
Oxymetazoline Hydrochloride/Tetracaine Hydrochloride	Tier C — Watch / trade	-
Naproxen Sodium/Sumatriptan Succinate	Tier C — Watch / trade	-
Desvenlafaxine Succinate Hydrate	Tier C — Watch / trade	-
Desvenlafaxine	Tier C — Watch / trade	-
Tetracaine Hydrochloride	Tier C — Watch / trade	-
Sumatriptan Succinate	Tier C — Watch / trade	-
Rivastigmine Tartrate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Ribociclib SuccinateOriginator routesteps: 9total yield: 45.7 g

5-bromo-2,4-dichloropyrimidine→cyclopentanamine→5-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine→prop-2-yn-1-ol→3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol→(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol→dimethylamine→2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→tert-butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate→5-chloro-2-nitropyridine→piperazine→1-(6-nitropyridin-3-yl)piperazine→tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

Oxymetazoline Hydrochloride/Tetracaine HydrochlorideOptimised routesteps: 10total yield: /

4-Aminobenzoic acid sodium salt→4-(Butylamino)benzoic acid→p-Chlorobenzoic acid→4-Bromobenzoic acid→4-Iodobenzoic acid→Butylamine→4-(Butylamino)benzoic acid ethyl ester→2-(Dimethylamino)ethanol hydrochloride→2-Chloroethanol→4-(Butylamino)benzoic acid 2-chloroethyl ester→N-Methylmethanamine→n-Butyl bromide→N,N-Dimethylaminoethanol→4-Aminobenzoic acid 2-(dimethylamino)ethyl ester→4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester

Naproxen Sodium/Sumatriptan SuccinateOptimised routesteps: 6total yield: /

1-(4-aminophenyl)-N-methylmethanesulfonamide→1-(3-hydrazineylphenyl)-N-methylmethanesulfonamide→2-(phenylthio)acetaldehyde→(E)-N-methyl-1-(3-(2-(2-(phenylthio)ethylidene)hydrazineyl)phenyl)methanesulfonamide→N-methyl-1-(3-(phenylthio)-1H-indol-5-yl)methanesulfonamide→1-(1H-indol-5-yl)-N-methylmethanesulfonamide→dimethylamine→N,N-dimethyl-2-(5-((N-methylsulfamoyl)methyl)-1H-indol-3-yl)-2-oxoacetamide→1-(3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide

Desvenlafaxine Succinate HydrateOriginator routesteps: 5total yield: 325 g

2-(4-methoxyphenyl)acetic acid→dimethylamine→2-(4-methoxyphenyl)-N,N-dimethylacetamide→2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)-N,N-dimethylacetamide→DESV-005→4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol

DesvenlafaxineOptimised routesteps: 7total yield: 5.8g(Desvenlafaxine (Free))

2-(4-Hydroxyphenyl)acetic acid→2-(4-Hydroxyphenyl)acetyl chloride→Dimethylamine→2-(4-Hydroxyphenyl)-N,N-dimethylacetamide→2-[4-[tert-Butyl(dimethyl)silyloxy]phenyl]-N,N-dimethylacetamide→Cyclohexanone→2-[4-[tert-Butyl(dimethyl)silyloxy]phenyl]-2-(1-hydroxycyclohexyl)-N,N-dimethylacetamide→4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol→2-(1-Hydroxycyclohexyl)-2-(4-hydroxyphenyl)-N,N-dimethylacetamide

DesvenlafaxineOptimised routesteps: 8total yield: 5.13g(Desvenlafaxine succinate (API))

1-(4-Hydroxyphenyl)ethanone→1-[4-(Benzyloxy)phenyl]ethanone→1-[4-(benzyloxy)phenyl]-2-bromoethan-1-one→Dimethylamine→1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethanone hydrobromide→1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethanol hydrochloride→2-[4-(Benzyloxy)phenyl]-2-chloro-N,N-dimethylethanamine hydrochloride→Cyclohexanone→1-{1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethyl}cyclohexan-1-ol→4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol

Tetracaine HydrochlorideOptimised routesteps: 10total yield: /

Sumatriptan SuccinateOptimised routesteps: 6total yield: /

Rivastigmine TartrateOptimised routesteps: 8total yield: /

1-(3-Hydroxyphenyl)ethanone→1-(3-Methoxyphenyl)ethanone→(1E)-1-(3-Methoxyphenyl)ethanone oxime→1-(3-Methoxyphenyl)ethanamine→1(S)-(3-Methoxyphenyl)ethylamine 2(S)-hydroxy-2-phenylacetate→1(S)-(3-Methoxyphenyl)-N,N-dimethylethylamine→(-)-3-((1S)-1-(Dimethylamino)ethyl)phenol→Potassium 3-[(1S)-1-(dimethylamino)ethyl]phenolate→N-Ethyl-N-methylcarbamic chloride→Ethyl(methyl)carbamic bromide→(S)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate→1(R)-(3-Methoxyphenyl)-N,N-dimethylethylamine 2(S)-hydroxy-2-phenylacetate→1(R)-(3-Methoxyphenyl)-N,N-dimethylethylamine→(1R)-1-(3-Methoxyphenyl)ethanol→(1R)-1-(3-Methoxyphenyl)ethyl methanesulfonate→Dimethylamine anhydrous→N-[(1Z)-1-(3-Methoxyphenyl)ethylidene]methanamine→N-Boc-[1(S)-(3-Methoxyphenyl)ethyl]-N-methylamine

Rivastigmine TartrateOptimised routesteps: 4total yield: /

1-(Benzyloxy)-3-ethenylbenzene→(-)-3-((1S)-1-(Dimethylamino)ethyl)phenol→(2S)-2-[3-(Benzyloxy)phenyl]oxirane→Dimethylamine anhydrous→(2R)-2-[3-(Benzyloxy)phenyl]-2-(dimethylamino)ethan-1-ol→(2R)-2-[3-(Benzyloxy)phenyl]-2-(dimethylamino)ethyl methanesulfonate

Rivastigmine TartrateOptimised routesteps: 6total yield: /

1-(3-Hydroxyphenyl)ethanone→3-[1(R)-Hydroxyethyl]phenol→3-[(1R)-1-[(Methanesulfonyl)oxy]ethyl]phenyl methanesulfonate→Dimethylamine anhydrous→3-[(1S)-1-(Dimethylamino)ethyl]phenyl methanesulfonate→(-)-3-((1S)-1-(Dimethylamino)ethyl)phenol→N-Ethyl-N-methylcarbamic chloride→(S)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate→3-Acetylphenyl ethyl(methyl)carbamate→3-[(1R)-1-Hydroxyethyl]phenyl ethyl(methyl)carbamate→(1R)-1-(3-[[Ethyl(methyl)carbamoyl]oxy]phenyl)ethyl methanesulfonate

Rivastigmine TartrateOptimised routesteps: 3total yield: /

3-Acetylphenyl ethyl(methyl)carbamate→3-[(1S)-1-Hydroxyethyl]phenyl ethyl(methyl)carbamate→Dimethylamine anhydrous→(S)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate→3-[(1R)-1-Hydroxyethyl]phenyl ethyl(methyl)carbamate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6- carboxamide Pharmaceutical Intermediates	On request	On request	On request	—

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