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CAS 127-17-3
2-Oxopropionic acid2-Oxopropanoic acid
Codes: Enalapril-050, Ephedrine Sulfate-026
Application context (from source-drug indications)
Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypotensionEphedrine SulfateEssential hypertensionEnalapril Maleate/Folic AcidHeart failureEnalapril MaleateHypertensionEnalapril MaleateMyocardial infarctionEnalapril MaleateAngina pectorisEnalapril MaleateLeft ventricular dysfunctionEnalapril MaleateSolid tumourEnalapril Maleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Ephedrine Sulfate | Tier C — Watch / trade | - |
| Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Enalapril Maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 4total yield: 3.28g(Enalapril-054)
Bitter almond→2-Oxopropionic acid→Potassium (3E)-2-oxo-4-phenylbut-3-enoate→(2R,3E)-2-Hydroxy-4-phenylbut-3-enoic acid→2(R)-Hydroxy-4-phenylbutyric acid→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate
(3E)-2-Oxo-4-phenylbut-3-enoic acid→2-Methylpropan-2-amine→2-Methylpropan-2-amine hydrogen chloride→3(E)-N-(tert-Butyl)-2-oxo-4-phenylbutenamide→(2S,3E)-N-tert-Butyl-2-hydroxy-4-phenylbut-3-enamide→(2S)-N-tert-Butyl-2-hydroxy-4-phenylbutanamide→(2S)-2-Hydroxy-4-phenylbutanoic acid→Ethyl 2(S)-hydroxy-4-phenylbutyrate→Benzaldehyde→2-Oxopropanoic acid→Non-denatured ethanol
Ethyl phenyl ketone→1-Phenylpropane-1,2-dione 2-oxime→(1R,2E)-2-(Hydroxyimino)-1-phenylpropan-1-ol→(1R)-1-Hydroxy-1-phenylpropan-2-one→Methylamine→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol→Benzaldehyde→2-Oxopropionic acid
Bitter almond→2-Oxopropionic acid→Potassium (3E)-2-oxo-4-phenylbut-3-enoate→(2R,3E)-2-Hydroxy-4-phenylbut-3-enoic acid→2(R)-Hydroxy-4-phenylbutyric acid→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate
(3E)-2-Oxo-4-phenylbut-3-enoic acid→2-Methylpropan-2-amine→2-Methylpropan-2-amine hydrogen chloride→3(E)-N-(tert-Butyl)-2-oxo-4-phenylbutenamide→(2S,3E)-N-tert-Butyl-2-hydroxy-4-phenylbut-3-enamide→(2S)-N-tert-Butyl-2-hydroxy-4-phenylbutanamide→(2S)-2-Hydroxy-4-phenylbutanoic acid→Ethyl 2(S)-hydroxy-4-phenylbutyrate→Benzaldehyde→2-Oxopropanoic acid→Non-denatured ethanol
Bitter almond→2-Oxopropionic acid→Potassium (3E)-2-oxo-4-phenylbut-3-enoate→(2R,3E)-2-Hydroxy-4-phenylbut-3-enoic acid→2(R)-Hydroxy-4-phenylbutyric acid→Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate
(3E)-2-Oxo-4-phenylbut-3-enoic acid→2-Methylpropan-2-amine→2-Methylpropan-2-amine hydrogen chloride→3(E)-N-(tert-Butyl)-2-oxo-4-phenylbutenamide→(2S,3E)-N-tert-Butyl-2-hydroxy-4-phenylbut-3-enamide→(2S)-N-tert-Butyl-2-hydroxy-4-phenylbutanamide→(2S)-2-Hydroxy-4-phenylbutanoic acid→Ethyl 2(S)-hydroxy-4-phenylbutyrate→Benzaldehyde→2-Oxopropanoic acid→Non-denatured ethanol
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