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CAS 2133-40-6
Methyl L-prolinate hydrogen chloridemethyl L-prolinate hydrochloride
Codes: Enalapril-077, VILD-016, EPTI-026
Application context (from source-drug indications)
Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilEssential hypertensionEnalapril Maleate/Folic AcidType 2 diabetesVildagliptinSchizophreniaVildagliptinDyslipidaemiaVildagliptinInsulin resistanceVildagliptinType 1 diabetesVildagliptinDiabetesVildagliptinHeart failureEnalapril MaleateHypertensionEnalapril MaleateMyocardial infarctionEnalapril MaleateAngina pectorisEnalapril MaleateLeft ventricular dysfunctionEnalapril MaleateSolid tumourEnalapril MaleateUnstable anginaEptifibatideMyocardial infarctionEptifibatideIschaemic strokeEptifibatideAcute coronary syndromeEptifibatideSickle cell diseaseEptifibatideST段抬高型心肌梗死Eptifibatide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Vildagliptin | Tier B — Position early | - |
| Enalapril Maleate | Tier C — Watch / trade | - |
| Eptifibatide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
L-Alanine→N-Boc-2(S)-aminopropanoic acid→(4R)-4-Amino-1,3-oxazolidine-2,5-dione→Methyl L-prolinate hydrogen chloride→Methyl N-(tert-butoxycarbonyl)-L-alanyl-L-prolinate→N-(tert-Butoxycarbonyl)-L-alanyl-L-proline→L-Proline→L-Alanyl-L-proline→2-Oxo-4-phenylbutyric acid ethyl ester→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
L-Alanine→N-Boc-2(S)-aminopropanoic acid→(4R)-4-Amino-1,3-oxazolidine-2,5-dione→Methyl L-prolinate hydrogen chloride→Methyl N-(tert-butoxycarbonyl)-L-alanyl-L-prolinate→N-(tert-Butoxycarbonyl)-L-alanyl-L-proline→L-Proline→L-Alanyl-L-proline→2-Oxo-4-phenylbutyric acid ethyl ester→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
(S)-pyrrolidine-2-carboxamide→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine hydrochloride→tert-butyl 2-bromoacetate→tert-butyl ((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycinate→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→methyl L-prolinate hydrochloride
(S)-pyrrolidine-2-carboxamide→(3s,5s,7s)-adamantan-1-amine hydrochloride→tert-butyl 2-bromoacetate→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→methyl L-prolinate hydrochloride→tert-butyl ((3s,5s,7s)-adamantan-1-yl)glycinate→((3s,5s,7s)-adamantan-1-yl)glycine→tert-butyl (S)-2-carbamoylpyrrolidine-1-carboxylate
L-Alanine→N-Boc-2(S)-aminopropanoic acid→(4R)-4-Amino-1,3-oxazolidine-2,5-dione→Methyl L-prolinate hydrogen chloride→Methyl N-(tert-butoxycarbonyl)-L-alanyl-L-prolinate→N-(tert-Butoxycarbonyl)-L-alanyl-L-proline→L-Proline→L-Alanyl-L-proline→2-Oxo-4-phenylbutyric acid ethyl ester→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
2-aminoacetic acid→methyl glycinate hydrochloride→(S)-2-(((benzyloxy)carbonyl)amino)-6-guanidinohexanoic acid→(S)-methyl 2-(2-amino-6-guanidinohexanamido)acetate→3-((acetamidomethyl)thio)propanoic acid→(S)-10-(4-guanidinobutyl)-2,8,11-trioxo-5-thia-3,9,12-triazatetradecan-14-oic acid→(S)-methyl 1-((S)-2-((S)-2-amino-4-(tert-butoxy)-4-oxobutanamido)-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→(S)-1-((10S,16S,19S)-19-((1H-indol-3-yl)methyl)-16-(2-(tert-butoxy)-2-oxoethyl)-10-(4-guanidinobutyl)-2,8,11,14,17-pentaoxo-5-thia-3,9,12,15,18-pentaazaicosan-20-oyl)pyrrolidine-2-carboxylic acid→(R)-3-((acetamidomethyl)thio)-2-aminopropanamide→(S)-pyrrolidine-2-carboxylic acid→methyl L-prolinate hydrochloride→(S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid→(S)-methyl 1-((S)-2-amino-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→(S)-2-(((benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid
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