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CAS 57044-25-4
(R)-Glycidol(R)-oxiran-2-ylmethanol
Codes: Bisoprolol-027, SELALD-002
Application context (from source-drug indications)
HypertensionAmlodipine Besylate/Bisoprolol FumarateEssential hypertensionAmlodipine Besylate/Bisoprolol FumarateHypertensionBisoprolol FumarateAngina pectorisBisoprolol FumarateChronic obstructive pulmonary diseaseBisoprolol FumarateCardiac and vascular disordersBisoprolol FumarateAcute coronary syndromeBisoprolol FumarateFastingBisoprolol FumarateBiliary cirrhosisSeladelpar lysine dihydrateSclerosing cholangitisSeladelpar lysine dihydrateLiver cirrhosisSeladelpar lysine dihydrateHepatic function declineSeladelpar lysine dihydrateFibrosisSeladelpar lysine dihydrateNon-alcoholic steatohepatitisSeladelpar lysine dihydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Amlodipine Besylate/Bisoprolol Fumarate | Tier C — Watch / trade | - |
| Bisoprolol Fumarate | Tier C — Watch / trade | - |
| Seladelpar lysine dihydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-([2-[(Propan-2-yl)oxy]ethoxy]methyl)phenyl methanesulfonate→(R)-Glycidol→(2S)-2-[[4-([2-[(Propan-2-yl)oxy]ethoxy]methyl)phenoxy]methyl]oxirane→(-)-1-[4-(2-Isopropoxyethoxymethyl)phenoxy]-3-(isopropylamino)-2(S)-propanol→But-2-enedioic acid (2S)-1-[(propan-2-yl)amino]-3-[4-([2-[(propan-2-yl)oxy]ethoxy]methyl)phenoxy]propan-2-ol→4-[(2-Isopropoxyethoxy)methyl]phenol→Monoisopropylamine
4-([2-[(Propan-2-yl)oxy]ethoxy]methyl)phenyl methanesulfonate→(R)-Glycidol→(2S)-2-[[4-([2-[(Propan-2-yl)oxy]ethoxy]methyl)phenoxy]methyl]oxirane→(-)-1-[4-(2-Isopropoxyethoxymethyl)phenoxy]-3-(isopropylamino)-2(S)-propanol→But-2-enedioic acid (2S)-1-[(propan-2-yl)amino]-3-[4-([2-[(propan-2-yl)oxy]ethoxy]methyl)phenoxy]propan-2-ol→4-[(2-Isopropoxyethoxy)methyl]phenol→Monoisopropylamine
4-(trifluoromethyl)phenol→(R)-oxiran-2-ylmethanol→(S)-2-((4-(trifluoromethyl)phenoxy)methyl)oxirane→ethyl 2-(4-mercapto-2-methylphenoxy)acetate→ethyl (R)-2-(4-((2-hydroxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetate→ethyl (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetate→(R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid→ethyl 2-(o-tolyloxy)acetate→ethyl 2-(4-(chlorosulfonyl)-2-methylphenoxy)acetate→(R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid compound with (S)-2,6-diaminohexanoic acid (1:1)
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