Abivertinib
Tier C — Watch / tradeAbivertinib
Targets：BTK, EGFR T790M
Indications (approved)：Non-small cell lung cancer, Non-Hodgkin lymphoma, Lymphoma, Chronic lymphocytic leukaemia, Diffuse large B-cell lymphoma, Mantle cell lymphoma, Prostate cancer, COVID-19
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| AVITI-001 | 90213-66-4Available | 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine |
| AVITI-002 | 442847-52-1 | 2,4-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine |
| AVITI-003 | 554-84-7 | 3-nitrophenol |
| AVITI-004 | 1557268-35-5 | 2-chloro-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine |
| AVITI-005 | 221198-99-8 | 3-fluoro-4-(4-methylpiperazin-1-yl)aniline |
| AVITI-006 | 1557268-58-2 | N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine |
| AVITI-007 | 1557268-61-7 | 4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine |
| AVITI-008 | 814-68-6Available | acryloyl chloride |
| AVITI-009 | 1557268-64-0 | N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide |
| AVITI-010 | 1557267-50-1 | N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide |
Frequently asked questions
What are the approved indications of Abivertinib?
Approved indications include: Non-small cell lung cancer, Non-Hodgkin lymphoma, Lymphoma, Chronic lymphocytic leukaemia, Diffuse large B-cell lymphoma, Mantle cell lymphoma, Prostate cancer, COVID-19.
When does the Abivertinib patent expire?
No public expiry year is available for Abivertinib yet; this page updates once verified.
How many synthesis routes are recorded for Abivertinib?
1 synthesis routes are recorded; the shortest is 7 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Abivertinib intermediates?
2 intermediate CAS of Abivertinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Abivertinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-08