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Eptazocine hydrobromide
Tier C — Watch / tradeEptazocine hydrobromide
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Originator
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First approval
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Expiry (public)
No sales data
Peak sales
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Type
Targets：MOR1, KOR1
Brand：Sedapain
Indications (approved)：Cancer pain, Postoperative pain
Regional status
US
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EU
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China
Approved
2006-05-25
Japan
Approved
1987-01-12
Synthetic routes & intermediates8 routes
Originator routes × 0Optimised (non-patent) × 8Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 5 · Total yield /
M1—M2—M3—M4—M5—API · Eptazocine hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| - | - | (1R,9S)-1-methyl-11-azatricyclo[7.4.1.0(2,7)]tetradeca-2(7),3,5-trien-4-ol |
| - | - | ethyl (1R,9S)-4-hydroxy-1-methyl-11-azatricyclo[7.4.1.0(2,7)]tetradeca-2(7),3,5-triene-11-carboxylate |
| - | - | (1R,9R)-4-(benzyloxy)-1,11-dimethyl-11-azatricyclo[7.4.1.0(2,7)]tetradeca-2(7),3,5-trien-8-one |
| - | - | (1R,9S)-4-methoxy-1,11-dimethyl-11-azatricyclo[7.4.1.0(2,7)]tetradeca-2,4,6-triene |
| - | - | (6S,8R)-6-(bromomethyl)-8-methyl-8-[2-(methylamino)ethyl]-5,6,7,8-tetrahydronaphthalen-2-ol |
OptimisedRoute 2Steps 3 · Total yield /
M1—M2—M3—API · Eptazocine hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| - | - | (4R)-6-methoxy-4-methyl-4-[2-(methylamino)ethyl]-1,2,3,4-tetrahydronaphthalen-1-one |
| - | - | (1R,9R)-4-methoxy-1,11-dimethyl-11-azatricyclo[7.4.1.0(2,7)]tetradeca-2(7),3,5-trien-8-one |
| - | - | (1R,9R)-4-methoxy-1,11-dimethyl-11-azatricyclo[7.4.1.0(2,7)]tetradeca-2(7),3,5-trien-8-ol |
OptimisedRoute 3Steps 1 · Total yield /
M174958-17-1API · Eptazocine hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| - | 74958-17-1 | (1S,6S)-10-Methoxy-1,4-dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonine |
OptimisedRoute 4Steps 7 · Total yield /
M11224714-08-2M23756-30-7M31430074-21-7M41430074-22-8M51430074-33-1M650-00-0M7—M8—M9—M10—API · Eptazocine hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| - | 1224714-08-2 | (4R)-4-Benzyl-3-[3-(4-methoxyphenyl)propanoyl]-1,3-oxazolidin-2-one |
| - | 3756-30-7 | Methylallyl iodide |
| - | 1430074-21-7 | (2R)-2-[(4-Methoxyphenyl)methyl]-4-methylpent-4-en-1-ol |
| - | 1430074-22-8 | 1-[(2R)-2-(Azidomethyl)-4-methylpent-4-en-1-yl]-4-methoxybenzene |
| - | 1430074-33-1 | N-[(2R)-2-[(4-Methoxyphenyl)methyl]-4-methylpent-4-en-1-yl]-4-methylbenzene-1-sulfonamide |
| - | 50-00-0Available | Formalin |
| - | - | (1S,6R)-10-Methoxy-1-methyl-4-(4-methylbenzene-1-sulfonyl)-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonine |
| - | - | (1S,6R)-10-Methoxy-1-methyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonine |
| - | - | (1S,6R)-1,4-Dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonin-10-ol |
| - | - | (1S,6R)-10-Methoxy-1,4-dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonine |
OptimisedRoute 5Steps 8 · Total yield 378g(Eptazocine-030)
M14746-97-8M25470-11-1M3180918-12-1M42087469-16-5M52087469-17-6M6172090-55-0M774-88-4M8879399-10-7M9824-94-2M102087469-19-8M1182160-88-1M1282160-89-2API · Eptazocine hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| - | 4746-97-8 | 1,4-Dioxaspiro[4.5]decan-8-one |
| - | 5470-11-1Available | Hydroxylamine hydrochloride |
| - | 180918-12-1 | N-{1,4-dioxaspiro[4.5]decan-8-ylidene}hydroxylamine |
| - | 2087469-16-5 | N-[(Methanesulfonyl)oxy]-1,4-dioxaspiro[4.5]decan-8-imine |
| - | 2087469-17-6 | 10-[(4-Methoxyphenyl)methyl]-8-methyl-1,4-dioxa-8-azaspiro[4.6]undecan-9-one |
| - | 172090-55-0 | 1,4-Dioxa-8-azaspiro[4.6]undecan-9-one |
| - | 74-88-4Available | Iodomethane |
| - | 879399-10-7 | 8-Methyl-1,4-dioxa-8-azaspiro[4.6]undecan-9-one |
| - | 824-94-2 | 4-Methoxybenzyl chloride |
| - | 2087469-19-8 | 4-Nitrobenzoic acid 10-[(4-methoxyphenyl)methyl]-8-methyl-1,4-dioxa-8-azaspiro[4.6]undecane |
| - | 82160-88-1 | 6-[(4-Methoxyphenyl)methyl]-1-methylazepan-4-one |
| - | 82160-89-2 | 6-[(4-Methoxyphenyl)methyl]-1,4-dimethylazepan-4-ol |
OptimisedRoute 6Steps 4 · Total yield 8.2g(Eptazocine)
M12087469-20-1M22087469-21-2M354782-45-5M4—M582160-89-2API · Eptazocine hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| - | 2087469-20-1 | 3-[(4-Methoxyphenyl)methyl]-1,5-dimethyl-2,3,6,7-tetrahydro-1H-azepine |
| - | 2087469-21-2 | 3-[(4-Methoxyphenyl)methyl]-1,5-dimethyl-2,3,4,7-tetrahydro-1H-azepine |
| - | 54782-45-5 | 10-Methoxy-1,4-dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonine |
| - | - | (1S,6R)-10-Methoxy-1,4-dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonine |
| - | 82160-89-2 | 6-[(4-Methoxyphenyl)methyl]-1,4-dimethylazepan-4-ol |
OptimisedRoute 7Steps 6 · Total yield /
M1107623-21-2M2—M32222923-20-6M4593-51-1M5—M62222922-73-6M7713482-37-2M854782-51-3M950-00-0API · Eptazocine hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| - | 107623-21-2 | 3-Benzyloxyiodobenzene |
| - | - | 6-Iodo-3-methylhex-2(Z)-en-1-ol |
| - | 2222923-20-6 | [7-(Benzyloxy)-1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl]acetaldehyde |
| - | 593-51-1 | Methanamine hydrochloride |
| - | - | 1,4-Dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonin-10-ol hydrogen bromide |
| - | 2222922-73-6 | 2-[7-(Benzyloxy)-1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylethan-1-amine |
| - | 713482-37-2 | 10-(Benzyloxy)-1,4-dimethyl-1,2,3,4,5,6-hexahydro-7H-1,6-methano-4-benzazonin-7-one |
| - | 54782-51-3 | 1,4-Dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonin-10-ol |
| - | 50-00-0Available | Formaldehyde |
OptimisedRoute 8Steps 6 · Total yield 106g(Eptazocine-046)
M11204-23-5M2105-36-2M332859-75-9M42671129-02-3M5122818-69-3M62671129-03-4M72671129-04-5M874-89-5M92671129-05-6API · Eptazocine hydrobromide
| Code | CAS No. | Intermediate |
|---|---|---|
| - | 1204-23-5 | 7-Methoxy-1-methyl-3,4-dihydronaphthalen-2-one |
| - | 105-36-2Available | 2-Bromoacetic acid ethyl ester |
| - | 32859-75-9 | Ethyl (7-methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)acetate |
| - | 2671129-02-3 | Ethyl (2-hydroxy-7-methoxy-1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)acetate |
| - | 122818-69-3 | 2-(7-Methoxy-1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-N-methylethan-1-amine |
| - | 2671129-03-4 | Ethyl (7-methoxy-1-methyl-1,4-dihydronaphthalen-1-yl)acetate |
| - | 2671129-04-5 | Ethyl (7-methoxy-1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)acetate |
| - | 74-89-5 | Methylamine |
| - | 2671129-05-6 | 2-(7-Methoxy-1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-N-methylacetamide |
Frequently asked questions
What are the approved indications of Eptazocine hydrobromide?
Approved indications include: Cancer pain, Postoperative pain.
When does the Eptazocine hydrobromide patent expire?
No public expiry year is available for Eptazocine hydrobromide yet; this page updates once verified.
How many synthesis routes are recorded for Eptazocine hydrobromide?
8 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Eptazocine hydrobromide intermediates?
4 intermediate CAS of Eptazocine hydrobromide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Eptazocine hydrobromide intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-21