Berzosertib
Tier C — Watch / tradeBerzosertib
Targets：ATR
Indications (approved)：Leiomyosarcoma, Neuroendocrine tumour, Solid tumour, Lung cancer, Squamous cell carcinoma, Small cell lung cancer, Oesophageal cancer, Gastric cancer
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| BERZO-001 | 24241-18-7 | 3,5-dibromopyrazin-2-amine |
| BERZO-002 | 1066-54-2Available | ethynyltrimethylsilane |
| BERZO-003 | 875781-41-2 | 5-bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-amine |
| BERZO-004 | 1225062-32-7 | - |
| BERZO-005 | 850567-98-5 | (4-(isopropylsulfonyl)phenyl)boronic acid |
| BERZO-006 | 1232423-98-1 | - |
| BERZO-007 | 36288-37-6 | (Z)-N-hydroxy-4-methylbenzimidoyl chloride |
| BERZO-008 | 1232424-00-8 | - |
| BERZO-009 | 1232424-02-0 | - |
| Berzosertib | - | 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine |
Frequently asked questions
What are the approved indications of Berzosertib?
Approved indications include: Leiomyosarcoma, Neuroendocrine tumour, Solid tumour, Lung cancer, Squamous cell carcinoma, Small cell lung cancer, Oesophageal cancer, Gastric cancer.
When does the Berzosertib patent expire?
No public expiry year is available for Berzosertib yet; this page updates once verified.
How many synthesis routes are recorded for Berzosertib?
1 synthesis routes are recorded; the shortest is 6 steps with 13.6 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Berzosertib intermediates?
1 intermediate CAS of Berzosertib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Berzosertib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-11