Galunisertib
Tier C — Watch / tradeGalunisertib
Targets：TGFBR1
Indications (approved)：Amyotrophic lateral sclerosis, Peritoneal cancer, Nasopharyngeal carcinoma, Colorectal cancer, Prostate cancer, Rectal cancer, Liver cancer, Glioblastoma
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| GALU-001 | 106-40-1Available | 4-bromoaniline |
| GALU-002 | 78-94-4 | but-3-en-2-one |
| GALU-003 | 41037-28-9 | 6-bromo-4-methylquinoline |
| GALU-004 | 13602-11-4 | methyl 6-methylpicolinate |
| GALU-005 | 476472-28-3 | 2-(6-bromoquinolin-4-yl)-1-(6-methylpyridin-2-yl)ethan-1-one |
| GALU-006 | 20386-22-5 | 1-aminopyrrolidin-2-one hydrochloride |
| GALU-007 | 476473-54-8 | (Z)-1-((2-(6-bromoquinolin-4-yl)-1-(6-methylpyridin-2-yl)ethylidene)amino)pyrrolidin-2-one |
| GALU-008 | 476474-52-9 | 6-bromo-4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline |
| GALU-009 | 476475-44-2 | methyl 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxylate |
Frequently asked questions
What are the approved indications of Galunisertib?
Approved indications include: Amyotrophic lateral sclerosis, Peritoneal cancer, Nasopharyngeal carcinoma, Colorectal cancer, Prostate cancer, Rectal cancer, Liver cancer, Glioblastoma.
When does the Galunisertib patent expire?
No public expiry year is available for Galunisertib yet; this page updates once verified.
How many synthesis routes are recorded for Galunisertib?
1 synthesis routes are recorded; the shortest is 6 steps with 1.10 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Galunisertib intermediates?
1 intermediate CAS of Galunisertib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Galunisertib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-12