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CAS 1012057-17-8

4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl acetate hydrochloride

Codes: NRC-2694-006

Application context (from source-drug indications)

转移性上皮癌NRC-2694

Source drugs (routes using this intermediate)

DrugTierExpiry
NRC-2694Tier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

NRC-2694Originator routesteps: 7total yield: 91.4 g (NRC-2694 Hydrochloride)
6,7-dimethoxyquinazolin-4(3H)-one→6-hydroxy-7-methoxyquinazolin-4(3H)-one→7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate→4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride→3-ethynylaniline→4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl acetate hydrochloride→4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-ol→4-(3-chloropropyl)morpholine→N-(3-ethynylphenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine hydrochloride

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