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CAS 1071809-52-3
4-Fluoro-2,3,5,6-tetradeutero-benzoyl chloride
Codes: (II)1078735-3-a
Application context (from source-drug indications)
Breast cancerImlunestrant TosylateMetastatic breast cancerImlunestrant TosylateMetastatic cancerImlunestrant TosylateOvarian cancerImlunestrant TosylateEndometrial cancerImlunestrant TosylateColorectal cancerImlunestrant Tosylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Imlunestrant Tosylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-Bromo-3-chloro-7-methoxyquinoline→4-Fluoro-2,3,5,6-tetradeutero-benzoyl chloride→(3-Chloro-7-methoxyquinolin-4-yl)[4-fluoro-2,3,5,6-tetradeutero-phenyl]methanone→(3-Chloro-7-hydroxyquinolin-4-yl)[4-fluoro-2,3,5,6-tetradeutero-phenyl]methanone→[2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid→[4-Fluoro-2,3,5,6-tetradeutero-phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol→[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→4-[[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl](hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol→(±)-5-[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl]-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol
Intermediates available on this site
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