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CAS 1199809-26-1
(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
Codes: AT-527-004
Application context (from source-drug indications)
Hepatitis CBemnifosbuvirCOVID-19BemnifosbuvirLiver cirrhosisBemnifosbuvirChronic hepatitis CBemnifosbuvirHepatic function declineBemnifosbuvirRenal impairmentBemnifosbuvir
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Bemnifosbuvir | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate→((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate→6-chloro-9H-purin-2-amine→(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate→(2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol→isopropyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate
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