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CAS 1229704-06-6
(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetaldehyde (1:1)
Codes: IDAS-006
Application context (from source-drug indications)
Solid tumourIdasanutlinAcute myeloid leukaemiaIdasanutlinPolycythaemia veraIdasanutlinLeukaemiaIdasanutlinAcute lymphoblastic leukaemiaIdasanutlinNeuroblastomaIdasanutlin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Idasanutlin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(3-chloro-2-fluorophenyl)ethan-1-one→2-(4-chloro-2-fluorophenyl)acetonitrile→(Z)-2-(4-chloro-2-fluoro-6-methylphenyl)-3-(3-chloro-2-fluorophenyl)acrylonitrile→tert-butyl (E)-2-((3,3-dimethylbutylidene)amino)acetate→tert-butyl (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxylate→(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetaldehyde (1:1)→(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxylic acid→methyl 4-amino-3-methoxybenzoate→methyl 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoate
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