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CAS 13143-47-0
1-(4-aminophenyl)pyridin-2(1H)-one
Codes: ZIFAXA-003
Application context (from source-drug indications)
Venous thrombosisZifaxabanPulmonary embolismZifaxaban
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Zifaxaban | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Zifaxaban→4-iodoaniline→pyridin-2(1H)-one→1-(4-aminophenyl)pyridin-2(1H)-one→(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione→(R)-2-(2-hydroxy-3-((4-(2-oxopyridin-1(2H)-yl)phenyl)amino)propyl)isoindoline-1,3-dione→(S)-2-((2-oxo-3-(4-(2-oxopyridin-1(2H)-yl)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione→(S)-5-(aminomethyl)-3-(4-(2-oxopyridin-1(2H)-yl)phenyl)oxazolidin-2-one hydrochloride→5-chlorothiophene-2-carbonyl chloride
Intermediates available on this site
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