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CAS 1332837-31-6
benzyl ((((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate
Codes: NUC-3373
Application context (from source-drug indications)
Colorectal cancerFosifloxuridine nafalbenamideNon-small cell lung cancerFosifloxuridine nafalbenamideMelanomaFosifloxuridine nafalbenamideHodgkin's diseaseFosifloxuridine nafalbenamide间皮组织肿瘤Fosifloxuridine nafalbenamideSquamous cell carcinomaFosifloxuridine nafalbenamide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Fosifloxuridine nafalbenamide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
benzyl ((((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate→naphthalen-1-ol→naphthalen-1-yl phosphorodichloridate→benzyl L-alaninate 4-methylbenzenesulfonate→benzyl (chloro(naphthalen-1-yloxy)phosphoryl)-L-alaninate→5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
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