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CAS 1352227-15-6
(R)-4-(2-chloro-6-((methylthio)methyl)pyrimidin-4-yl)-3-methylmorpholine
Codes: AZD-6738-007
Application context (from source-drug indications)
Non-small cell lung cancerCeralasertibSmall cell lung cancerCeralasertib三阴性乳腺癌CeralasertibMelanomaCeralasertibSolid tumourCeralasertibOsteosarcomaCeralasertib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ceralasertib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 2,6-dichloropyrimidine-4-carboxylate→(R)-3-methylmorpholine→methyl (R)-2-chloro-6-(3-methylmorpholino)pyrimidine-4-carboxylate→(R)-(2-chloro-6-(3-methylmorpholino)pyrimidin-4-yl)methanol→(R)-(2-chloro-6-(3-methylmorpholino)pyrimidin-4-yl)methyl methanesulfonate→(R)-4-(2-chloro-6-(iodomethyl)pyrimidin-4-yl)-3-methylmorpholine→(R)-4-(2-chloro-6-((methylthio)methyl)pyrimidin-4-yl)-3-methylmorpholine→(R)-4-(2-chloro-6-(((S)-methylsulfinyl)methyl)pyrimidin-4-yl)-3-methylmorpholine→(R)-4-(2-chloro-6-(((S)-methylsulfinyl)methyl)pyrimidin-4-yl)-3-methylmorpholine→N-(((2-chloro-6-((R)-3-methylmorpholino)pyrimidin-4-yl)methyl)(methyl)(oxo)-l6-sulfaneylidene)-2,2,2-trifluoroacetamide→(1-(2-chloro-6-((R)-3-methylmorpholino)pyrimidin-4-yl)cyclopropyl)(imino)(methyl)-l6-sulfanone→tert-butyl 4-bromo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate→tert-butyl 4-(4-((R)-3-methylmorpholino)-6-(1-(S-methylsulfonimidoyl)cyclopropyl)pyrimidin-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate
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