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CAS 1443531-67-6
4-amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazine-7-carbaldehyde
Codes: ROGAR-008
Application context (from source-drug indications)
SarcomaRogaratinibGastrointestinal stromal tumourRogaratinibBreast cancerRogaratinibMetastatic breast cancerRogaratinibNon-small cell lung cancerRogaratinibUrothelial carcinomaRogaratinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Rogaratinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-methoxy-4-methylbenzenesulfonyl chloride→2-methoxy-4-methylbenzenethiol→2-bromo-1,1-diethoxyethane→(2,2-diethoxyethyl)(2-methoxy-4-methylphenyl)sulfane→7-methoxy-5-methylbenzo[b]thiophene→(7-methoxy-5-methylbenzo[b]thiophen-2-yl)boronic acid→4-amino-5-bromo-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazine-7-carbaldehyde→4-amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazine-7-carbaldehyde→piperazin-2-one→4-aminopyrrolo[2,1-f][1,2,4]triazine-6-carbonitrile→ethyl 4-aminopyrrolo[2,1-f][1,2,4]triazine-6-carboxylate→(4-aminopyrrolo[2,1-f][1,2,4]triazin-6-yl)methanol→6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine→4-amino-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazine-7-carbaldehyde→4-((4-amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)methyl)piperazin-2-one
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