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CAS 146013-28-7
N-(tert-butyl)-5-isobutylthiophene-2-sulfonamide
Codes: M-024-003
Application context (from source-drug indications)
COVID-19BuloxibutidIdiopathic pulmonary fibrosisBuloxibutid雷诺氏病BuloxibutidSystemic sclerosisBuloxibutid
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Buloxibutid | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
butyl ((3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophen-2-yl)sulfonyl)carbamate→thiophene-2-sulfonyl chloride→N-(tert-butyl)thiophene-2-sulfonamide→N-(tert-butyl)-5-isobutylthiophene-2-sulfonamide→(2-(N-(tert-butyl)sulfamoyl)-5-isobutylthiophen-3-yl)boronic acid→1-(4-bromobenzyl)-1H-imidazole→3-(4-((1H-imidazol-1-yl)methyl)phenyl)-N-(tert-butyl)-5-isobutylthiophene-2-sulfonamide→3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophene-2-sulfonamide→butyl carbonochloridate→1-bromo-4-(bromomethyl)benzene
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