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CAS 1565797-40-1
2-((1E,3E)-4-(6-(methylamino)pyridin-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-ol
Codes: APN-1607-008
Application context (from source-drug indications)
Alzheimer's diseaseFlorzolotauMild cognitive impairmentFlorzolotauCognitive impairmentFlorzolotau神经变性FlorzolotauDiagnostic agentFlorzolotau进行性核上性麻痹Florzolotau
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Florzolotau | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-bromo-2-nitropyridine→3,3-diethoxyprop-1-ene→(E)-3-(6-nitropyridin-3-yl)acrylaldehyde→diethyl ((6-methoxybenzo[d]thiazol-2-yl)methyl)phosphonate→6-methoxy-2-((1E,3E)-4-(6-nitropyridin-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazole→5-((1E,3E)-4-(6-methoxybenzo[d]thiazol-2-yl)buta-1,3-dien-1-yl)pyridin-2-amine→5-((1E,3E)-4-(6-methoxybenzo[d]thiazol-2-yl)buta-1,3-dien-1-yl)-N-methylpyridin-2-amine→2-((1E,3E)-4-(6-(methylamino)pyridin-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-ol→2-((tert-butyldimethylsilyl)oxy)-3-(fluoro-18F)propan-1-ol→5-((1E,3E)-4-(6-(2-((tert-butyldimethylsilyl)oxy)-3-(fluoro-18F)propoxy)benzo[d]thiazol-2-yl)buta-1,3-dien-1-yl)-N-methylpyridin-2-amine
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