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CAS 1639014-72-4
(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(difluoromethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Codes: Mefatinib
Application context (from source-drug indications)
Non-small cell lung cancerMifanertinib MaleateSolid tumourMifanertinib Maleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Mifanertinib Maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(difluoromethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide→N-(3-chloro-4-fluorophenyl)-7-(difluoromethoxy)-6-nitroquinazolin-4-amine→N4-(3-chloro-4-fluorophenyl)-7-(difluoromethoxy)quinazoline-4,6-diamine→2-(diethoxyphosphoryl)acetic acid→diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-(difluoromethoxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate
Intermediates available on this site
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