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CAS 1672665-51-8
4-(3-bromo-5-fluorophenoxy)-7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolane]
Codes: PT-2385-016
Application context (from source-drug indications)
von Hippel-Lindau syndromePT-2385SarcomaPT-2385Renal cell carcinomaPT-2385肾肿瘤PT-2385GlioblastomaPT-2385
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| PT-2385 | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-bromo-5-fluorophenol→4-fluoro-7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolane]→4-(3-bromo-5-fluorophenoxy)-7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolane]→3-fluoro-5-((7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolan]-4-yl)oxy)benzonitrile→butan-1-amine→(E)-3-((1-(butylimino)-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
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