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CAS 1824712-65-3
Benzyl L-histidyl-L-prolyl-D-alaninate hydrochloride
Codes: (VIII)692039-1-a,(VIII)692039-1-b, (VII)692039-2-a
Application context (from source-drug indications)
冠状病毒感染TRV-120027COVID-19TRV-120027Acute decompensated heart failureTRV-120027Kidney diseaseTRV-120027Heart failureTRV-120027
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| TRV-120027 | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid→Ethoxycarbonyl N-(tert-butoxycarbonyl)-L-valinate→(-)-alpha-Amino-p-hydroxyhydrocinnamic acid→N-(tert-Butoxycarbonyl)-L-valyl-L-tyrosine→Ethoxycarbonyl N-(tert-butoxycarbonyl)-L-valyl-L-tyrosinate→(2S,3S)-alpha-Amino-beta-merthylvaleric acid→N-(tert-Butoxycarbonyl)-L-valyl-L-tyrosyl-L-isoleucine→Benzyl L-histidyl-L-prolyl-D-alaninate hydrochloride→Benzyl L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-D-alaninate hydrochloride→N-[(Benzyloxy)carbonyl]-N-methylglycyl-L-arginine→Benzyl N-[(benzyloxy)carbonyl]-N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-D-alaninate hydrochloride→N-Methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-D-alanine acetate
Benzyl L-histidyl-L-prolyl-D-alaninate hydrochloride→N-[(Benzyloxy)carbonyl]-N-methylglycyl-L-arginine→(2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid→Ethoxycarbonyl 1-(tert-butoxycarbonyl)-L-prolinate→2-{[(Benzyloxy)carbonyl](methyl)amino}acetic acid→Benzyl D-alaninate 4-methylbenzenesulfonate→Benzyl L-prolyl-D-alaninate hydrochloride→(2S)-2-{[(tert-Butoxy)carbonyl]amino}-3-(1H-imidazol-5-yl)propanoic acid→Benzyl N-(tert-butoxycarbonyl)-L-histidyl-L-prolyl-D-alaninate→Pentafluorophenyl trifluoroacetate→Pentafluorophenyl N-[(benzyloxy)carbonyl]-N-methylglycinate→(S)-(+)-Arginine
Pentafluorophenyl N-[(benzyloxy)carbonyl]-N-methylglycinate→N5-(N-Nitrocarbamimidoyl)-L-ornithine→N-[(Benzyloxy)carbonyl]-N-methylglycyl-N5-(N-nitrocarbamimidoyl)-L-ornithine→L-Valyl-L-tyrosyl-L-isoleucine hydrochloride→N-(tert-Butoxycarbonyl)-L-valyl-L-tyrosyl-L-isoleucine→N-[(Benzyloxy)carbonyl]-N-methylglycyl-N5-(N-nitrocarbamimidoyl)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucine→Benzyl L-histidyl-L-prolyl-D-alaninate hydrochloride→Benzyl N-[(benzyloxy)carbonyl]-N-methylglycyl-N5-(N-nitrocarbamimidoyl)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-D-alaninate
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