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CAS 2033057-21-3
2-chloro-6-methylthieno[3,2-d]pyrimidine
Codes: MAX-40279-003
Application context (from source-drug indications)
Solid tumourNefextinib hemifumarateColorectal cancerNefextinib hemifumarateMyelodysplastic syndromeNefextinib hemifumarateAcute myeloid leukaemiaNefextinib hemifumarateIdiopathic pulmonary fibrosisNefextinib hemifumarateMetastatic cancerNefextinib hemifumarate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Nefextinib hemifumarate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
MAX-40279→2,4-dichloro-6-methylthieno[3,2-d]pyrimidine→2-chloro-6-methyl-3,4-dihydrothieno[3,2-d]pyrimidine→2-chloro-6-methylthieno[3,2-d]pyrimidine→2-chloro-7-iodo-6-methylthieno[3,2-d]pyrimidine→(4-fluoro-2-methoxyphenyl)boronic acid→2-chloro-7-(4-fluoro-2-methoxyphenyl)-6-methylthieno[3,2-d]pyrimidine→tert-butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate→tert-butyl 4-(4-((7-(4-fluoro-2-methoxyphenyl)-6-methylthieno[3,2-d]pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)piperidine-1-carboxylate→4-nitro-1H-pyrazole→tert-butyl 4-hydroxypiperidine-1-carboxylate→tert-butyl 4-(4-nitro-1H-pyrazol-1-yl)piperidine-1-carboxylate
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