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CAS 2180923-64-0
7-(Chloromethyl)-6-(4-chlorophenyl)spiro[3.5]non-6-ene
Codes: (XV)992511-1-a,(XV)992511-1-b
Application context (from source-drug indications)
Chronic lymphocytic leukaemiaLisaftoclaxAcute promyelocytic leukaemiaLisaftoclaxMyelodysplastic syndromeLisaftoclaxAcute myeloid leukaemiaLisaftoclaxDiffuse large B-cell lymphomaLisaftoclaxSystemic lupus erythematosusLisaftoclax
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lisaftoclax | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Cyclobutanone→1-(Triphenylphosphoranylidene)-2-propanone→1-Cyclobutylidenepropan-2-one→Carbonic acid dimethyl diester→Spiro[3.5]nonane-6,8-dione→8-(2-Methylpropoxy)spiro[3.5]non-7-en-6-one→Spiro[3.5]non-7-en-6-one→Spiro[3.5]nonan-6-one→1,3-Dimethyl propanedioate→Methyl 6-oxospiro[3.5]nonane-7-carboxylate→Methyl 6-(((trifluoromethyl)sulfonyl)oxy) spiro[3.5]non-6-ene-7-carboxylate→(4-Chlorophenyl)boranediol→Methyl 6-(4-chlorophenyl)spiro[3.5]non-6-ene-7-carboxylate→[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methanol→7-(Chloromethyl)-6-(4-chlorophenyl)spiro[3.5]non-6-ene
3-Nitro-4-[[(2S)-1,4-dioxan-2-yl]methylamino]benzenesulfonamide→7-(Chloromethyl)-6-(4-chlorophenyl)spiro[3.5]non-6-ene→Ethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(piperazin-1 -yl)benzoate→Ethyl 4-(4-[[6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazin-1-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzoate→4-(4-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazin-1-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzoic acid
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