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CAS 3584-65-4
2-(trichloromethyl)-1H-benzo[d]imidazole
Codes: IMARIK-010
Application context (from source-drug indications)
HypertensionImarikiren hydrochlorideDiabetic nephropathyImarikiren hydrochlorideHepatic function declineImarikiren hydrochlorideRenal impairmentImarikiren hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Imarikiren hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
pyridine-3,5-dicarboxylic acid→dimethyl pyridine-3,5-dicarboxylate→1-(tert-butyl) 3,5-dimethyl piperidine-1,3,5-tricarboxylate→1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)piperidine-3-carboxylic acid→(3S,5R)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)piperidine-3-carboxylic acid→1-(tert-butyl) 3-methyl (3R,5S)-5-isocyanatopiperidine-1,3-dicarboxylate→1-(tert-butyl) 3-methyl (3R,5S)-5-(((benzyloxy)carbonyl)amino)piperidine-1,3-dicarboxylate→1-(tert-butyl) 3-methyl (3R,5S)-5-aminopiperidine-1,3-dicarboxylate→1-(tert-butyl) 3-methyl (3R,5S)-5-(isobutylamino)piperidine-1,3-dicarboxylate→2-(trichloromethyl)-1H-benzo[d]imidazole→1-(tert-butyl) 3-methyl (3R,5S)-5-(N-isobutyl-1H-benzo[d]imidazole-2-carboxamido)piperidine-1,3-dicarboxylate→4-methoxybutyl methanesulfonate→1-(tert-butyl) 3-methyl (3R,5S)-5-(N-isobutyl-1-(4-methoxybutyl)-1H-benzo[d]imidazole-2-carboxamido)piperidine-1,3-dicarboxylate→(3R,5S)-1-(tert-butoxycarbonyl)-5-(N-isobutyl-1-(4-methoxybutyl)-1H-benzo[d]imidazole-2-carboxamido)piperidine-3-carboxylic acid→tert-butyl (3S,5R)-3-(N-isobutyl-1-(4-methoxybutyl)-1H-benzo[d]imidazole-2-carboxamido)-5-(morpholine-4-carbonyl)piperidine-1-carboxylate→N-isobutyl-1-(4-methoxybutyl)-N-((3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl)-1H-benzo[d]imidazole-2-carboxamide→N-isobutyl-1-(4-methoxybutyl)-N-((3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl)-1H-benzo[d]imidazole-2-carboxamide hydrochloride
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