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CAS 57338-21-3
ethyl (E)-2-cyano-3-(dimethylamino)acrylate
Codes: HDM-201-003
Application context (from source-drug indications)
SarcomaSiremadlinHaematological malignancySiremadlinHepatic function declineSiremadlinAcute myeloid leukaemiaSiremadlinColorectal cancerSiremadlinMetastatic cancerSiremadlin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Siremadlin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one→ethyl 2-cyanoacetate→1,1-diethoxy-N,N-dimethylmethanamine→ethyl (E)-2-cyano-3-(dimethylamino)acrylate→ethyl 1-isopropyl-1H-imidazole-4-carboxylate→ethyl 2-bromo-1-isopropyl-1H-imidazole-4-carboxylate→4-chlorobenzaldehyde→ethyl 2-bromo-5-((4-chlorophenyl)(hydroxy)methyl)-1-isopropyl-1H-imidazole-4-carboxylate→3-amino-5-chloro-1-methylpyridin-2(1H)-one→ethyl 2-bromo-5-(((5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-isopropyl-1H-imidazole-4-carboxylate→2-bromo-5-(((5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-isopropyl-1H-imidazole-4-carboxylic acid→2-bromo-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one→(2,4-dimethoxypyrimidin-5-yl)boronic acid→5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one→5-chloro-3-nitropyridin-2-ol→5-chloro-1-methyl-3-nitropyridin-2(1H)-one
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