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CAS 57852-42-3

(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-5-(hydroxymethyl)-8,10-dimethyl-11a-(prop-1-en-2-yl)-6,6a,9a,10,11,11a-hexahydro-3aH-2,9b-epoxyazuleno[5',4':3,4]benzo[1,2-d][1,3]dioxol-7(3bH)-one

Codes: Resiniferatoxin-001

Application context (from source-drug indications)

OsteoarthritisResiniferatoxin顽固性疼痛Resiniferatoxin慢性膝关节痛ResiniferatoxinKnee arthritisResiniferatoxinMorton神经瘤ResiniferatoxinCancer painResiniferatoxin

Source drugs (routes using this intermediate)

DrugTierExpiry
ResiniferatoxinTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

ResiniferatoxinOptimised routesteps: 1total yield: /
Benzeneacetic acid, 4-hydroxy-3-methoxy-, [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methyl ester→(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-5-(hydroxymethyl)-8,10-dimethyl-11a-(prop-1-en-2-yl)-6,6a,9a,10,11,11a-hexahydro-3aH-2,9b-epoxyazuleno[5',4':3,4]benzo[1,2-d][1,3]dioxol-7(3bH)-one→2-(4-hydroxy-3-methoxyphenyl)acetic acid

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