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CAS 67-71-0
1-(Methylsulfonyl)methane
Codes: (XV)989842-1-b, (IX)989842-2-b
Application context (from source-drug indications)
Plaque psoriasisMufemilastUlcerative colitisMufemilastBehçet's syndromeMufemilastPsoriasisMufemilastChronic obstructive pulmonary diseaseMufemilastAtopic dermatitisMufemilast
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Mufemilast | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→3-Hydroxy-4-methoxybenzaldehyde→1-Iodoethane→(3-Ethoxy-4-methoxy-phenyl)-methanone→1,1,1-Trimethyl-N-(trimethylsilyl)silanamine lithium salt→1-(Methylsulfonyl)methane→1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonyl-N-trimethylsilylethanamine→1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→3-Ethoxy-4-methoxybenzonitrile→1-(Methylsulfonyl)methane→1-(3-Ethoxy-4-methoxyphenyl)-2-(mesyl)ethenamine→1-(3-Ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethan-1-one→(S)-(-)-1-Phenylethylamine→1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-N-[(1S)-1-phenylethyl]ethenamine→(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)-N-[(1S)-1-phenylethyl]ethan-1-amine→(3-Ethoxy-4-methoxy-phenyl)-methanone→(+)-(R)-2-Methylpropane-2-sulfinamide→(SR)-N-[(3-Ethoxy-4-methoxyphenyl)methyl]-2-methylpropane-2-sulfinamide→N-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2-methylpropane-2-sulfinamide
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