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CAS 771579-27-2

3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one

Codes: Zeprumetostat-010

Application context (from source-drug indications)

Peripheral T-cell lymphomaZeprumetostatLymphomaZeprumetostatT-cell lymphomaZeprumetostatMyelodysplastic syndromeZeprumetostatAcute lymphoblastic leukaemiaZeprumetostatAcute myeloid leukaemiaZeprumetostat

Source drugs (routes using this intermediate)

DrugTierExpiry
ZeprumetostatTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

ZeprumetostatOptimised routesteps: 3total yield: 5.0 g
6-bromo-5-ethyl-2-(piperidin-1-ylmethyl)benzofuran-4-carboxylic acid hydrogen chloride→3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one→6-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-2-(piperidin-1-ylmethyl)benzofuran-4-carboxamide→tetrahydro-2H-pyran-4-amine→N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-2-(piperidin-1-ylmethyl)-6-((tetrahydro-2H-pyran-4-yl)amino)benzofuran-4-carboxamide

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