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CAS 848942-61-0
2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide
Codes: Sapitinib
Application context (from source-drug indications)
Non-small cell lung cancerSapitinibMetastatic breast cancerSapitinibNeoplasmSapitinibBreast cancerSapitinibOesophageal cancerSapitinibGastric cancerSapitinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Sapitinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-hydroxy-4-methoxybenzonitrile→tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate→tert-butyl 4-(5-cyano-2-methoxyphenoxy)piperidine-1-carboxylate→4-methoxy-3-(piperidin-4-yloxy)benzonitrile hydrochloride→2-(4-(5-cyano-2-methoxyphenoxy)piperidin-1-yl)-N-methylacetamide→2-(4-(5-cyano-2-methoxy-4-nitrophenoxy)piperidin-1-yl)-N-methylacetamide→2-(4-(4-amino-5-cyano-2-methoxyphenoxy)piperidin-1-yl)-N-methylacetamide→(E)-N,N'-bis(3-chloro-2-fluorophenyl)formimidamide→3-chloro-2-fluoroaniline→triethoxymethane→2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide
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