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CAS 869886-90-8
4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid
Codes: ULIXER-009
Application context (from source-drug indications)
Multiple myelomaUlixertinibLymphomaUlixertinibNon-Hodgkin lymphomaUlixertinibHepatoblastomaUlixertinibOsteosarcomaUlixertinib横纹肌肉瘤Ulixertinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ulixertinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,2,2-trichloro-1-(1H-pyrrol-2-yl)ethan-1-one→2,2,2-trichloro-1-(4-iodo-1H-pyrrol-2-yl)ethanone→methyl 4-iodo-1H-pyrrole-2-carboxylate→methyl 4-iodo-1-tosyl-1H-pyrrole-2-carboxylate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrole-2-carboxylate→5-chloro-4-iodo-N-isopropylpyridin-2-amine→methyl 4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-1-tosyl-1H-pyrrole-2-carboxylate→4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid→(S)-2-amino-2-(3-chlorophenyl)ethanol→5-chloro-2-fluoro-4-iodopyridine→Ulixertinib
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