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CAS 917022-13-0
tert-butyl (((1r,4r)-4-(((4-amino-6-chloropyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)(3-((tert-butoxycarbonyl)(cyclohexyl)amino)propyl)carbamate
Codes: BURIX-011
Application context (from source-drug indications)
Haematopoietic stem cell transplantationBurixafor HydrobromideProstate cancerBurixafor HydrobromideAcute myeloid leukaemiaBurixafor HydrobromideMultiple myelomaBurixafor HydrobromideNon-Hodgkin lymphomaBurixafor HydrobromideHodgkin's diseaseBurixafor Hydrobromide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Burixafor Hydrobromide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N2-(((1r,4r)-4-(aminomethyl)cyclohexyl)methyl)-6-chloropyrimidine-2,4-diamine→(1r,4r)-4-(((tert-butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid→tert-butyl (((1r,4r)-4-carbamoylcyclohexyl)methyl)carbamate→tert-butyl (((1r,4r)-4-cyanocyclohexyl)methyl)carbamate→tert-butyl (((1r,4r)-4-(aminomethyl)cyclohexyl)methyl)carbamate→2,6-dichloropyrimidin-4-amine→tert-butyl (((1r,4r)-4-(((4-amino-6-chloropyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)carbamate→tert-butyl cyclohexyl(3-oxopropyl)carbamate→tert-butyl (3-((((1r,4r)-4-(((4-amino-6-chloropyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)amino)propyl)(cyclohexyl)carbamate→tert-butyl (((1r,4r)-4-(((4-amino-6-chloropyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)(3-((tert-butoxycarbonyl)(cyclohexyl)amino)propyl)carbamate→tert-butyl (((1r,4r)-4-(((4-amino-6-(piperazin-1-yl)pyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)(3-((tert-butoxycarbonyl)(cyclohexyl)amino)propyl)carbamate→diethyl vinylphosphonate→tert-butyl (((1r,4r)-4-(((4-amino-6-(4-(2-(diethoxyphosphoryl)ethyl)piperazin-1-yl)pyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)(3-((tert-butoxycarbonyl)(cyclohexyl)amino)propyl)carbamate→Burixafor Hydrobromide→(1r,4r)-4-(aminomethyl)cyclohexanecarboxylic acid
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.