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CAS 92973-39-2
(R)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyacetic acid
Codes: AZD-5069-011
Application context (from source-drug indications)
Head and neck squamous cell carcinomaAZD-5069Castration-resistant prostate cancerAZD-5069胰腺导管癌AZD-5069AsthmaAZD-5069Chronic obstructive pulmonary diseaseAZD-5069Lung diseaseAZD-5069
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| AZD-5069 | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
AZD-5069→1-(bromomethyl)-2,3-difluorobenzene→6-hydroxy-2-thioxo-2,3-dihydropyrimidin-4(1H)-one→2-((2,3-difluorobenzyl)thio)pyrimidine-4,6-diol→4,6-dichloro-2-((2,3-difluorobenzyl)thio)pyrimidine→(R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethan-1-ol→4-chloro-2-((2,3-difluorobenzyl)thio)-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)pyrimidine→azetidine-1-sulfonamide→N-(2-((2,3-difluorobenzyl)thio)-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)pyrimidin-4-yl)azetidine-1-sulfonamide→(R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one→(R)-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,4-dihydroxyfuran-2(5H)-one→(R)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyacetic acid→methyl (R)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyacetate→methyl (R)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(tosyloxy)acetate→(S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyethyl 4-methylbenzenesulfonate→(S)-2,2-dimethyl-4-((R)-oxiran-2-yl)-1,3-dioxolane
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