Fexofenadine Hydrochloride

Tier C — Watch / trade

Sunovion Pharmaceuticals Inc

Originator

1996

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：HRH1

Brand：Raltiva, Telfast, Allegra, Axodin, Altiva, Allegra OD, Allegra Flash

Indications (approved)：Allergic rhinitis, Dermatitis, Pruritus, Eczema, Atopic dermatitis, Seasonal allergic rhinitis, Chronic urticaria

Regional status

Approved

1996-07-25

Approved

1996-03-11

China

Approved

2002-01-14

Japan

Approved

2000-09-22

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield /

FEXO-001826-55-1FEXO-0022173-69-5FEXO-00318755-52-7FEXO-0044635-59-0FEXO-005169032-11-5FEXO-006115-46-8FEXO-007191155-94-9FEXO-00876811-99-9FEXO-00976811-98-8API · Fexofenadine Hydrochloride

Code	CAS No.	Intermediate
FEXO-001	826-55-1	2-methyl-2-phenylpropanoic acid
FEXO-002	2173-69-5	2-methyl-2-phenylpropan-1-ol
FEXO-003	18755-52-7	2-methyl-2-phenylpropyl acetate
FEXO-004	4635-59-0	4-chlorobutanoyl chloride
FEXO-005	169032-11-5	2-(4-(4-chlorobutanoyl)phenyl)-2-methylpropyl acetate
FEXO-006	115-46-8	methanol
FEXO-007	191155-94-9	2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropyl acetate
FEXO-008	76811-99-9	1-(4-(1-hydroxy-2-methylpropan-2-yl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-one
FEXO-009	76811-98-8	2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoic acid

OptimisedRoute 2Steps 4 · Total yield /

FEXO-006115-46-8FEXO-01052787-37-8FEXO-0111990525-39-7FEXO-012207301-64-2FEXO-013207301-30-2FEXO-014174483-06-8API · Fexofenadine Hydrochloride

Code	CAS No.	Intermediate
FEXO-006	115-46-8	methanol
FEXO-010	52787-37-8	ethyl 2-(4-formylphenyl)-2-methylpropanoate
FEXO-011	1990525-39-7	(2-(1,3-dioxolan-2-yl)ethyl)magnesium bromide
FEXO-012	207301-64-2	ethyl 2-(4-(3-(1,3-dioxolan-2-yl)-1-hydroxypropyl)phenyl)-2-methylpropanoate
FEXO-013	207301-30-2	ethyl 2-(4-(5-hydroxytetrahydrofuran-2-yl)phenyl)-2-methylpropanoate
FEXO-014	174483-06-8	ethyl 2-(4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoate

OptimisedRoute 3Steps 5 · Total yield 3.30 g

FEXO-006115-46-8FEXO-01557625-74-8FEXO-016108-30-5FEXO-017479197-48-3FEXO-01864-04-0FEXO-019479197-52-9FEXO-020479197-54-1FEXO-021154825-96-4API · Fexofenadine Hydrochloride

Code	CAS No.	Intermediate
FEXO-006	115-46-8	methanol
FEXO-015	57625-74-8 Available	methyl 2-methyl-2-phenylpropanoate
FEXO-016	108-30-5	dihydrofuran-2,5-dione
FEXO-017	479197-48-3	4-(4-(1-methoxy-2-methyl-1-oxopropan-2-yl)phenyl)-4-oxobutanoic acid
FEXO-018	64-04-0	2-phenylethanamine
FEXO-019	479197-52-9	2-phenylethanamine 4-(4-(1-methoxy-2-methyl-1-oxopropan-2-yl)phenyl)-4-oxobutanoate
FEXO-020	479197-54-1	methyl 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)-4-oxobutanoyl)phenyl)-2-methylpropanoate
FEXO-021	154825-96-4	methyl 2-(4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoate

OptimisedRoute 4Steps 4 · Total yield 6.70 g

FEXO-006115-46-8FEXO-013207301-30-2FEXO-022154825-93-1FEXO-023394222-31-2FEXO-024154477-55-1API · Fexofenadine Hydrochloride

Code	CAS No.	Intermediate
FEXO-006	115-46-8	methanol
FEXO-013	207301-30-2	ethyl 2-(4-(5-hydroxytetrahydrofuran-2-yl)phenyl)-2-methylpropanoate
FEXO-022	154825-93-1	methyl 2-(4-(4-hydroxybut-1-yn-1-yl)phenyl)-2-methylpropanoate
FEXO-023	394222-31-2	methyl 2-(4-(4-bromobutanoyl)phenyl)-2-methylpropanoate
FEXO-024	154477-55-1	methyl 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoate

OptimisedRoute 5Steps 2 · Total yield 85.00 g

FEXO-025154825-95-3FEXO-024154477-55-1API · Fexofenadine Hydrochloride

Code	CAS No.	Intermediate
FEXO-025	154825-95-3	methyl 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)but-1-yn-1-yl)phenyl)-2-methylpropanoate
FEXO-024	154477-55-1	methyl 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoate

Frequently asked questions

What are the approved indications of Fexofenadine Hydrochloride?

Approved indications include: Allergic rhinitis, Dermatitis, Pruritus, Eczema, Atopic dermatitis, Seasonal allergic rhinitis, Chronic urticaria.

When does the Fexofenadine Hydrochloride patent expire?

No public expiry year is available for Fexofenadine Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Fexofenadine Hydrochloride?

5 synthesis routes are recorded; the shortest is 2 steps with 85.00 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Fexofenadine Hydrochloride intermediates?

1 intermediate CAS of Fexofenadine Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Fexofenadine Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-04