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Bimatoprost
Tier C — Watch / tradeBimatoprost
Allergan
Originator
2001
First approval
-
Expiry (public)
$0.76B ▲
Peak sales
Small molecule
Type
Targets：Prostanoid receptor
Brand：Latisse, DURYSTA, Lumigan/Latisse, Lumigan
Indications (approved)：Ocular hypertension, Glaucoma, 少毛症, Open-angle glaucoma
Regional status
US
Approved
2001-03-16
EU
Approved
2002-03-08
China
Approved
2005-04-20
Japan
Approved
2009-07-07
Synthetic routes & intermediates5 routes
Originator routes × 0Optimised (non-patent) × 5Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 9 · Total yield 11.5 g
BIMA-00139746-00-4BIMA-00239746-01-5BIMA-00341162-19-0BIMA-00455076-60-3BIMA-005908590-16-9BIMA-0061355995-17-3BIMA-00741639-74-1BIMA-008856240-62-5BIMA-00917814-85-6BIMA-01038344-08-0BIMA-01138315-47-8API · Bimatoprost
| Code | CAS No. | Intermediate |
|---|---|---|
| BIMA-001 | 39746-00-4 | (3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate |
| BIMA-002 | 39746-01-5 | (3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate |
| BIMA-003 | 41162-19-0 | dimethyl (2-oxo-4-phenylbutyl)phosphonate |
| BIMA-004 | 55076-60-3 | (3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate |
| BIMA-005 | 908590-16-9 | (3aR,4R,5R,6aS)-4-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate |
| BIMA-006 | 1355995-17-3 | (S,E)-1-((3aR,4R,5R,6aS)-5-(benzoyloxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-yl)-5-phenylpent-1-en-3-yl 4-nitrobenzoate |
| BIMA-007 | 41639-74-1 | (3aR,4R,5R,6aS)-5-hydroxy-4-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one |
| BIMA-008 | 856240-62-5 | (3aR,4R,5R,6aS)-4-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol |
| BIMA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| BIMA-010 | 38344-08-0 | (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoic acid |
| BIMA-011 | 38315-47-8 | methyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate |
OptimisedRoute 2Steps 18 · Total yield 22 g
BIMA-00917814-85-6BIMA-01298-01-1BIMA-013106-95-6BIMA-0146398-51-2BIMA-0151012036-78-0BIMA-0161190883-06-7BIMA-0171190883-07-8BIMA-0181190883-23-8BIMA-0191190883-08-9BIMA-0201190883-10-3BIMA-02181834-79-9BIMA-022876953-80-9BIMA-023474944-36-0BIMA-0241190883-18-1BIMA-0251190883-21-6BIMA-0261190883-22-7BIMA-027130209-76-6BIMA-028104-53-0BIMA-0294301-14-8BIMA-03067648-04-8BIMA-031183904-28-1BIMA-0321190883-17-0API · Bimatoprost
| Code | CAS No. | Intermediate |
|---|---|---|
| BIMA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| BIMA-012 | 98-01-1 | 1-vinylcyclopenta-1,3-diene |
| BIMA-013 | 106-95-6Available | 3-bromoprop-1-ene |
| BIMA-014 | 6398-51-2 | 1-(furan-2-yl)but-3-en-1-ol |
| BIMA-015 | 1012036-78-0 | tert-butyl((1-(furan-2-yl)but-3-en-1-yl)oxy)dimethylsilane |
| BIMA-016 | 1190883-06-7 | 4-((tert-butyldimethylsilyl)oxy)-4-(furan-2-yl)butane-1,2-diol |
| BIMA-017 | 1190883-07-8 | 3-((tert-butyldimethylsilyl)oxy)-3-(furan-2-yl)propanal |
| BIMA-018 | 1190883-23-8 | (Z)-8-((tert-butyldimethylsilyl)oxy)-8-(furan-2-yl)oct-5-enoic acid |
| BIMA-019 | 1190883-08-9 | isopropyl (Z)-8-((tert-butyldimethylsilyl)oxy)-8-(furan-2-yl)oct-5-enoate |
| BIMA-020 | 1190883-10-3 | isopropyl (Z)-8-(furan-2-yl)-8-hydroxyoct-5-enoate |
| BIMA-021 | 81834-79-9 | isopropyl (Z)-7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)hept-5-enoate |
| BIMA-022 | 876953-80-9 | isopropyl (R,Z)-7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)hept-5-enoate |
| BIMA-023 | 474944-36-0 | isopropyl (R,Z)-7-(3-((tert-butyldimethylsilyl)oxy)-5-oxocyclopent-1-en-1-yl)hept-5-enoate |
| BIMA-024 | 1190883-18-1 | (S,E)-tert-butyldimethyl((5-phenyl-1-(tributylstannyl)pent-1-en-3-yl)oxy)silane |
| BIMA-025 | 1190883-21-6 | isopropyl (Z)-7-((1R,2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoate |
| BIMA-026 | 1190883-22-7 | isopropyl (Z)-7-((1R,2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-5-hydroxycyclopentyl)hept-5-enoate |
| BIMA-027 | 130209-76-6 | isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate |
| BIMA-028 | 104-53-0 | 3-phenylpropanal |
| BIMA-029 | 4301-14-8 | ethynylmagnesium bromide |
| BIMA-030 | 67648-04-8 | 5-phenylpent-1-yn-3-ol |
| BIMA-031 | 183904-28-1 | (S)-5-phenylpent-1-yn-3-ol |
| BIMA-032 | 1190883-17-0 | (S,E)-5-phenyl-1-(tributylstannyl)pent-1-en-3-ol |
OptimisedRoute 3Steps 8 · Total yield /
BIMA-00341162-19-0BIMA-00917814-85-6BIMA-03364091-14-1BIMA-0341240483-13-9BIMA-0351240483-14-0BIMA-0361240483-15-1BIMA-0371240483-16-2BIMA-0381240483-17-3BIMA-0391240483-18-4BIMA-0401240483-19-5API · Bimatoprost
| Code | CAS No. | Intermediate |
|---|---|---|
| BIMA-003 | 41162-19-0 | dimethyl (2-oxo-4-phenylbutyl)phosphonate |
| BIMA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| BIMA-033 | 64091-14-1 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde |
| BIMA-034 | 1240483-13-9 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one |
| BIMA-035 | 1240483-14-0 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one |
| BIMA-036 | 1240483-15-1 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one |
| BIMA-037 | 1240483-16-2 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-ol |
| BIMA-038 | 1240483-17-3 | (Z)-7-((1R,2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-5-hydroxycyclopentyl)hept-5-enoic acid |
| BIMA-039 | 1240483-18-4 | methyl (Z)-7-((1R,2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-5-hydroxycyclopentyl)hept-5-enoate |
| BIMA-040 | 1240483-19-5 | (Z)-7-((1R,2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-5-hydroxycyclopentyl)-N-ethylhept-5-enamide |
OptimisedRoute 4Steps 14 · Total yield 360 mg
BIMA-00341162-19-0BIMA-00917814-85-6BIMA-01138315-47-8BIMA-04132233-40-2BIMA-04265025-94-7BIMA-04364982-34-9BIMA-0441384863-28-8BIMA-0451365263-79-1BIMA-0461365263-81-5BIMA-0471365263-83-7BIMA-0481631057-82-3BIMA-0491334395-03-7BIMA-0501334395-05-9BIMA-0512550-26-7BIMA-05231984-10-8BIMA-053352276-27-8API · Bimatoprost
| Code | CAS No. | Intermediate |
|---|---|---|
| BIMA-003 | 41162-19-0 | dimethyl (2-oxo-4-phenylbutyl)phosphonate |
| BIMA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| BIMA-011 | 38315-47-8 | methyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate |
| BIMA-041 | 32233-40-2 | (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one |
| BIMA-042 | 65025-94-7 | (3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one |
| BIMA-043 | 64982-34-9 | (3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate |
| BIMA-044 | 1384863-28-8 | (3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-hydroxyhexahydro-2H-cyclopenta[b]furan-5-yl benzoate |
| BIMA-045 | 1365263-79-1 | (Z)-7-((1R,2S,3R,5S)-3-(benzoyloxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxycyclopentyl)hept-5-enoic acid |
| BIMA-046 | 1365263-81-5 | (1R,2S,3R,4S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxy-3-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentyl benzoate |
| BIMA-047 | 1365263-83-7 | (1S,3R,4S,5R)-4-(hydroxymethyl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate |
| BIMA-048 | 1631057-82-3 | (1S,3R,4R,5R)-4-formyl-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate |
| BIMA-049 | 1334395-03-7 | (1R,3S,4R,5R)-4-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)-5-((E)-3-oxo-5-phenylpent-1-en-1-yl)cyclopentane-1,3-diyl dibenzoate |
| BIMA-050 | 1334395-05-9 | (1S,3R,4R,5R)-4-((E)-3-hydroxy-5-phenylpent-1-en-1-yl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate |
| BIMA-051 | 2550-26-7 | 4-phenylbutan-2-one |
| BIMA-052 | 31984-10-8 | 1-bromo-4-phenylbutan-2-one |
| BIMA-053 | 352276-27-8 | 1-iodo-4-phenylbutan-2-one |
OptimisedRoute 5Steps 11 · Total yield 82.6 mg
BIMA-008856240-62-5BIMA-028104-53-0BIMA-054696-59-3BIMA-0551933708-52-1BIMA-056—BIMA-057329313-32-8BIMA-0581513876-42-0BIMA-059—BIMA-0601201226-16-5BIMA-061115-19-5BIMA-0621644539-23-0BIMA-063329313-36-2BIMA-0642067-33-6BIMA-065179011-80-4API · Bimatoprost
| Code | CAS No. | Intermediate |
|---|---|---|
| BIMA-008 | 856240-62-5 | (3aR,4R,5R,6aS)-4-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol |
| BIMA-028 | 104-53-0 | 3-phenylpropanal |
| BIMA-054 | 696-59-3 | 2,5-dimethoxytetrahydrofuran |
| BIMA-055 | 1933708-52-1 | (3aR,6aS)-2-hydroxy-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-5-carbaldehyde |
| BIMA-056 | - | (3aR,6aS)-2-methoxy-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-5-carbaldehyde |
| BIMA-057 | 329313-32-8 | (S,E)-tert-butyl((1-iodo-5-phenylpent-1-en-3-yl)oxy)dimethylsilane |
| BIMA-058 | 1513876-42-0 | tert-butyl(((1E,3S)-1-((3aR,4R,6aS)-2-methoxy-5-(((trimethylsilyl)oxy)methylene)hexahydro-2H-cyclopenta[b]furan-4-yl)-5-phenylpent-1-en-3-yl)oxy)dimethylsilane |
| BIMA-059 | - | (3aR,4R,5R,6aS)-4-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-2-methoxyhexahydro-2H-cyclopenta[b]furan-5-ol |
| BIMA-060 | 1201226-16-5 | (5-(ethylamino)-5-oxopentyl)triphenylphosphonium bromide |
| BIMA-061 | 115-19-5 | 2-methylbut-3-yn-2-ol |
| BIMA-062 | 1644539-23-0 | (S)-5-((tert-butyldimethylsilyl)oxy)-2-methyl-7-phenylhept-3-yn-2-ol |
| BIMA-063 | 329313-36-2 | (S)-tert-butyldimethyl((5-phenylpent-1-yn-3-yl)oxy)silane |
| BIMA-064 | 2067-33-6Available | 5-bromopentanoic acid |
| BIMA-065 | 179011-80-4 | 5-bromo-N-ethylpentanamide |
Frequently asked questions
What are the approved indications of Bimatoprost?
Approved indications include: Ocular hypertension, Glaucoma, 少毛症, Open-angle glaucoma.
When does the Bimatoprost patent expire?
No public expiry year is available for Bimatoprost yet; this page updates once verified.
How many synthesis routes are recorded for Bimatoprost?
5 synthesis routes are recorded; the shortest is 8 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Bimatoprost intermediates?
2 intermediate CAS of Bimatoprost are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Bimatoprost intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-04