Alitretinoin

Tier C — Watch / trade

Alitretinoin

Eisai Co., Ltd.

Originator

1999

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：RXRG, RAR-β, RXRA, RAR-γ, RAR-α, RXRB

Brand：Toctino, Panrexin, Panretin

Indications (approved)：Kaposi's sarcoma

Regional status

Approved

1999-02-02

Withdrawn

China

Japan

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 83 mg

ALIT-001472-66-2ALIT-002303779-99-9ALIT-003850354-34-6ALIT-0043917-39-3ALIT-0051209-68-3ALIT-006950-51-6ALIT-007256518-45-3ALIT-008137273-43-9ALIT-009861043-74-5API · Alitretinoin

Code	CAS No.	Intermediate
ALIT-001	472-66-2	2-(2,6,6-trimethylcyclohex-1-en-1-yl)acetaldehyde
ALIT-002	303779-99-9	(E)-2-(2,6,6-trimethylcyclohex-1-en-1-yl)vinyl trifluoromethanesulfonate
ALIT-003	850354-34-6	(Z)-3-(tributylstannyl)but-2-en-1-ol
ALIT-004	3917-39-3	(2Z,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dien-1-ol
ALIT-005	1209-68-3	(2Z,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dienal
ALIT-006	950-51-6	1,3,3-trimethyl-2-((1E,3Z)-3-methylhexa-1,3-dien-5-yn-1-yl)cyclohex-1-ene
ALIT-007	256518-45-3	tributyl((1E,3Z,5E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hexa-1,3,5-trien-1-yl)stannane
ALIT-008	137273-43-9	(E)-ethyl 3-(((trifluoromethyl)sulfonyl)oxy)but-2-enoate
ALIT-009	861043-74-5	(2E,4E,6Z,8E)-ethyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate

OptimisedRoute 2Steps 5 · Total yield /

ALIT-009861043-74-5ALIT-0102408-37-9ALIT-011189633-82-7ALIT-012189633-81-6ALIT-0131370415-46-5ALIT-014256518-80-6API · Alitretinoin

Code	CAS No.	Intermediate
ALIT-009	861043-74-5	(2E,4E,6Z,8E)-ethyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate
ALIT-010	2408-37-9	2,2,6-trimethylcyclohexanone
ALIT-011	189633-82-7	(2,2,6-trimethylcyclohexylidene)hydrazine
ALIT-012	189633-81-6	2-iodo-1,3,3-trimethylcyclohex-1-ene
ALIT-013	1370415-46-5	dimethyl (2,6,6-trimethylcyclohex-1-en-1-yl)boronate
ALIT-014	256518-80-6	(2E,4E,6Z,8E)-ethyl 9-iodo-3,7-dimethylnona-2,4,6,8-tetraenoate

OptimisedRoute 3Steps 6 · Total yield /

ALIT-0051209-68-3ALIT-009861043-74-5ALIT-01514901-07-6ALIT-016116627-72-6ALIT-017173214-57-8ALIT-01841891-54-7ALIT-01941891-54-7API · Alitretinoin

Code	CAS No.	Intermediate
ALIT-005	1209-68-3	(2Z,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dienal
ALIT-009	861043-74-5	(2E,4E,6Z,8E)-ethyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate
ALIT-015	14901-07-6	(E)-2-(but-1-en-3-yn-1-yl)-1,3,3-trimethylcyclohex-1-ene
ALIT-016	116627-72-6	(E)-5-(2,6,6-trimethylcyclohex-1-en-1-yl)pent-4-en-2-ynenitrile
ALIT-017	173214-57-8	(2Z,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dienenitrile
ALIT-018	41891-54-7	ethyl (E)-4-(diethoxyphosphoryl)-3-methylbut-2-enoate
ALIT-019	41891-54-7	ethyl (E)-4-(diethoxyphosphoryl)-3-methylbut-2-enoate

OptimisedRoute 4Steps 6 · Total yield /

ALIT-009861043-74-5ALIT-01941891-54-7ALIT-020432-25-7ALIT-021116-26-7ALIT-022638-10-8ALIT-02371973-21-2ALIT-02494162-97-7ALIT-02526918-26-3API · Alitretinoin

Code	CAS No.	Intermediate
ALIT-009	861043-74-5	(2E,4E,6Z,8E)-ethyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate
ALIT-019	41891-54-7	ethyl (E)-4-(diethoxyphosphoryl)-3-methylbut-2-enoate
ALIT-020	432-25-7	2,6,6-trimethylcyclohex-1-enecarbaldehyde
ALIT-021	116-26-7	2,6,6-trimethylcyclohexa-1,3-dienecarbaldehyde
ALIT-022	638-10-8	ethyl 3-methylbut-2-enoate
ALIT-023	71973-21-2	4-methyl-6-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)-5,6-dihydro-2H-pyran-2-one
ALIT-024	94162-97-7	(2Z,4E)-3-methyl-5-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)penta-2,4-dienal
ALIT-025	26918-26-3	(2E,4E,6Z,8E)-ethyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)nona-2,4,6,8-tetraenoate

Frequently asked questions

What are the approved indications of Alitretinoin?

Approved indications include: Kaposi's sarcoma.

When does the Alitretinoin patent expire?

No public expiry year is available for Alitretinoin yet; this page updates once verified.

How many synthesis routes are recorded for Alitretinoin?

4 synthesis routes are recorded; the shortest is 5 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Alitretinoin intermediates?

All intermediates in Alitretinoin routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Alitretinoin intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-04