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Eplerenone
Tier C — Watch / tradeEplerenone
Pfizer Inc.
Originator
2002
First approval
-
Expiry (public)
$0.23B ▲
Peak sales
Small molecule
Type
Targets：MR
Brand：Selara, Inspra, EPLERENONEANDA, Elecor
Indications (approved)：Hypertension, Heart failure
Regional status
US
Approved
2002-09-27
EU
Phase II
2007-01-01
China
Approved
2021-04-09
Japan
Approved
2007-07-31
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 6 · Total yield 44.3 g
EPLE-001192569-17-8EPLE-00275-86-5EPLE-003192704-52-2EPLE-004192704-54-4EPLE-005192704-56-6EPLE-006192704-58-8EPLE-00795716-70-4API · Eplerenone
| Code | CAS No. | Intermediate |
|---|---|---|
| EPLE-001 | 192569-17-8 | (10R,11R,13S,17R)-11-hydroxy-10,13-dimethyl-1,3',4',8,9,10,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-002 | 75-86-5 | 2-hydroxy-2-methylpropanenitrile |
| EPLE-003 | 192704-52-2 | (2R,5'R,7'R,10'R,11'R,13'S)-18'-amino-11'-hydroxy-10',13'-dimethyl-3',5-dioxo-1',2',3',4,5,6',7',8',9',10',11',12',13',14',15',16'-hexadecahydro-3H,5'H-spiro[furan-2,17'-[4,7](metheno)cyclopenta[a]phenanthrene]-5'-carbonitrile |
| EPLE-004 | 192704-54-4 | (2R,5'S,7'R,10'R,11'R,13'S)-11'-hydroxy-10',13'-dimethyl-3',5,18'-trioxohexadecahydro-3H-spiro[furan-2,17'-[4,7]methanocyclopenta[a]phenanthrene]-5'(2'H)-carbonitrile |
| EPLE-005 | 192704-56-6 | methyl (7R,10R,11R,13S,17R)-11-hydroxy-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate |
| EPLE-006 | 192704-58-8 | methyl (7R,10R,11R,13S,17R)-10,13-dimethyl-11-((methylsulfonyl)oxy)-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate |
| EPLE-007 | 95716-70-4 | methyl (7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate |
OptimisedRoute 2Steps 5 · Total yield 7.45 g
EPLE-00795716-70-4EPLE-00895716-71-5EPLE-00995716-72-6EPLE-010188988-15-0EPLE-01195716-74-8API · Eplerenone
| Code | CAS No. | Intermediate |
|---|---|---|
| EPLE-007 | 95716-70-4 | methyl (7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate |
| EPLE-008 | 95716-71-5 | (10R,13S,17R)-10,13-dimethyl-1,3',4',8,10,12,13,14,15,16-decahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-009 | 95716-72-6 | (7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carbonitrile |
| EPLE-010 | 188988-15-0 | (7R,10S,13S,17R)-3-hydroxy-10,13-dimethyl-5'-oxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carbaldehyde |
| EPLE-011 | 95716-74-8 | (7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylic acid |
OptimisedRoute 3Steps 7 · Total yield /
EPLE-00795716-70-4EPLE-00895716-71-5EPLE-01195716-74-8EPLE-012534-22-5EPLE-013610785-40-5EPLE-014109-53-5EPLE-015610785-41-6EPLE-016—EPLE-017610785-45-0API · Eplerenone
| Code | CAS No. | Intermediate |
|---|---|---|
| EPLE-007 | 95716-70-4 | methyl (7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate |
| EPLE-008 | 95716-71-5 | (10R,13S,17R)-10,13-dimethyl-1,3',4',8,10,12,13,14,15,16-decahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-011 | 95716-74-8 | (7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylic acid |
| EPLE-012 | 534-22-5 | 2-methylfuran |
| EPLE-013 | 610785-40-5 | (7R,8R,10S,13S,14S,17R)-10,13-dimethyl-7-(5-methylfuran-2-yl)-1,3',4',6,7,8,10,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-014 | 109-53-5 | 2-methyl-1-(vinyloxy)propane |
| EPLE-015 | 610785-41-6 | (7R,8R,10S,13S,14S,17R)-10,13-dimethyl-7-((E)-4-oxopent-2-enoyl)-1,3',4',6,7,8,10,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-016 | - | (7R,8R,10S,13S,14S,17R)-7-(2-hydroxy-2-methoxyacetyl)-10,13-dimethyl-1,3',4',6,7,8,10,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-017 | 610785-45-0 | (1'R,2R,3a'R,7a'R,9a'S,12a'S,12b'R)-7a',9a'-dimethyl-1',3,4,6',7',7a',9',9a',11',12',12a',12b'-dodecahydro-2'H,5H-spiro[furan-2,10'-[1,3a]methanobenzo[b]indeno[5,4-d]oxepine]-2',5,5'(4'H)-trione |
OptimisedRoute 4Steps 5 · Total yield /
EPLE-001192569-17-8EPLE-00895716-71-5EPLE-017610785-45-0EPLE-018209253-91-8EPLE-0191263102-65-3EPLE-020115464-59-0EPLE-0211263102-67-5API · Eplerenone
| Code | CAS No. | Intermediate |
|---|---|---|
| EPLE-001 | 192569-17-8 | (10R,11R,13S,17R)-11-hydroxy-10,13-dimethyl-1,3',4',8,9,10,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-008 | 95716-71-5 | (10R,13S,17R)-10,13-dimethyl-1,3',4',8,10,12,13,14,15,16-decahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-017 | 610785-45-0 | (1'R,2R,3a'R,7a'R,9a'S,12a'S,12b'R)-7a',9a'-dimethyl-1',3,4,6',7',7a',9',9a',11',12',12a',12b'-dodecahydro-2'H,5H-spiro[furan-2,10'-[1,3a]methanobenzo[b]indeno[5,4-d]oxepine]-2',5,5'(4'H)-trione |
| EPLE-018 | 209253-91-8 | (10R,11R,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',8,9,10,11,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-11-yl methanesulfonate |
| EPLE-019 | 1263102-65-3 | (1'R,2R,3a'R,7a'R,9a'S)-7a',9a'-dimethyl-1',3,4,6',7',7a',9',9a',11',12',12a',12b'-dodecahydro-2'H,5H-spiro[furan-2,10'-[1,3a]methanobenzo[b]indeno[5,4-d]oxepine]-5,5'(4'H)-dione |
| EPLE-020 | 115464-59-0 | 3-methyl-3-(trifluoromethyl)dioxirane |
| EPLE-021 | 1263102-67-5 | (1'R,2R,2'S,3a'R,7a'R,9a'S)-2'-hydroxy-7a',9a'-dimethyl-1',3,4,6',7',7a',9',9a',11',12',12a',12b'-dodecahydro-2'H,5H-spiro[furan-2,10'-[1,3a]methanobenzo[b]indeno[5,4-d]oxepine]-5,5'(4'H)-dione |
OptimisedRoute 5Steps 6 · Total yield 3.06 g
EPLE-001192569-17-8EPLE-005192704-56-6EPLE-006192704-58-8EPLE-00795716-70-4EPLE-0221398078-03-9EPLE-023209253-72-5API · Eplerenone
| Code | CAS No. | Intermediate |
|---|---|---|
| EPLE-001 | 192569-17-8 | (10R,11R,13S,17R)-11-hydroxy-10,13-dimethyl-1,3',4',8,9,10,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-005 | 192704-56-6 | methyl (7R,10R,11R,13S,17R)-11-hydroxy-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate |
| EPLE-006 | 192704-58-8 | methyl (7R,10R,11R,13S,17R)-10,13-dimethyl-11-((methylsulfonyl)oxy)-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate |
| EPLE-007 | 95716-70-4 | methyl (7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate |
| EPLE-022 | 1398078-03-9 | (7R,8R,9S,10R,11R,13S,14S,17R)-11-hydroxy-10,13-dimethyl-7-(nitromethyl)-1,3',4',6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione |
| EPLE-023 | 209253-72-5 | (7R,8S,9S,10R,11R,13S,14S,17R)-11-hydroxy-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylic acid |
Frequently asked questions
What are the approved indications of Eplerenone?
Approved indications include: Hypertension, Heart failure.
When does the Eplerenone patent expire?
No public expiry year is available for Eplerenone yet; this page updates once verified.
How many synthesis routes are recorded for Eplerenone?
5 synthesis routes are recorded; the shortest is 5 steps with 7.45 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Eplerenone intermediates?
All intermediates in Eplerenone routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Eplerenone intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-04