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Diphenhydramine Hydrochloride

Tier C — Watch / trade

Diphenhydramine Hydrochloride

Johnson & Johnson
Originator
1946
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets:HRH1

Brand:Butix 2%, Benadryl

Indications (approved):Hypersensitivity reaction

Regional status

US
Phase III
2010-10-01
EU
-
China
Approved
1981-01-01
Japan
-

Synthetic routes & intermediates2 routes

Originator routes × 0Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 2 · Total yield /
DIPHEN-001101-81-5DIPHEN-002776-74-9DIPHEN-003108-01-0API · Diphenhydramine Hydrochloride
CodeCAS No.Intermediate
DIPHEN-001101-81-5diphenylmethane
DIPHEN-002776-74-9(bromomethylene)dibenzene
DIPHEN-003108-01-02-(dimethylamino)ethanol
OptimisedRoute 2Steps 2 · Total yield /
DIPHEN-003108-01-0DIPHEN-00491-01-0DIPHEN-005135513-20-1API · Diphenhydramine Hydrochloride
CodeCAS No.Intermediate
DIPHEN-003108-01-02-(dimethylamino)ethanol
DIPHEN-00491-01-0diphenylmethanol
DIPHEN-005135513-20-1benzhydryl methanesulfonate

Frequently asked questions

What are the approved indications of Diphenhydramine Hydrochloride?

Approved indications include: Hypersensitivity reaction.

When does the Diphenhydramine Hydrochloride patent expire?

No public expiry year is available for Diphenhydramine Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Diphenhydramine Hydrochloride?

2 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Diphenhydramine Hydrochloride intermediates?

All intermediates in Diphenhydramine Hydrochloride routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Diphenhydramine Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-04