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CAS 1190883-23-8
(Z)-8-((tert-butyldimethylsilyl)oxy)-8-(furan-2-yl)oct-5-enoic acid
Codes: BIMA-018
Application context (from source-drug indications)
Ocular hypertensionBimatoprost/Timolol MaleateOpen-angle glaucomaBimatoprost/Timolol MaleateGlaucomaBimatoprost/Timolol MaleateOcular hypertensionBimatoprostGlaucomaBimatoprost少毛症BimatoprostOpen-angle glaucomaBimatoprost白内障Bimatoprost瘢痕Bimatoprost
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Bimatoprost/Timolol Maleate | Tier C — Watch / trade | - |
| Bimatoprost | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4-carboxybutyl)triphenylphosphonium bromide→1-vinylcyclopenta-1,3-diene→3-bromoprop-1-ene→1-(furan-2-yl)but-3-en-1-ol→tert-butyl((1-(furan-2-yl)but-3-en-1-yl)oxy)dimethylsilane→4-((tert-butyldimethylsilyl)oxy)-4-(furan-2-yl)butane-1,2-diol→3-((tert-butyldimethylsilyl)oxy)-3-(furan-2-yl)propanal→(Z)-8-((tert-butyldimethylsilyl)oxy)-8-(furan-2-yl)oct-5-enoic acid→isopropyl (Z)-8-((tert-butyldimethylsilyl)oxy)-8-(furan-2-yl)oct-5-enoate→isopropyl (Z)-8-(furan-2-yl)-8-hydroxyoct-5-enoate→isopropyl (Z)-7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)hept-5-enoate→isopropyl (R,Z)-7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)hept-5-enoate→isopropyl (R,Z)-7-(3-((tert-butyldimethylsilyl)oxy)-5-oxocyclopent-1-en-1-yl)hept-5-enoate→(S,E)-tert-butyldimethyl((5-phenyl-1-(tributylstannyl)pent-1-en-3-yl)oxy)silane→isopropyl (Z)-7-((1R,2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoate→isopropyl (Z)-7-((1R,2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-5-hydroxycyclopentyl)hept-5-enoate→isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate→3-phenylpropanal→ethynylmagnesium bromide→5-phenylpent-1-yn-3-ol→(S)-5-phenylpent-1-yn-3-ol→(S,E)-5-phenyl-1-(tributylstannyl)pent-1-en-3-ol
(4-carboxybutyl)triphenylphosphonium bromide→1-vinylcyclopenta-1,3-diene→3-bromoprop-1-ene→1-(furan-2-yl)but-3-en-1-ol→tert-butyl((1-(furan-2-yl)but-3-en-1-yl)oxy)dimethylsilane→4-((tert-butyldimethylsilyl)oxy)-4-(furan-2-yl)butane-1,2-diol→3-((tert-butyldimethylsilyl)oxy)-3-(furan-2-yl)propanal→(Z)-8-((tert-butyldimethylsilyl)oxy)-8-(furan-2-yl)oct-5-enoic acid→isopropyl (Z)-8-((tert-butyldimethylsilyl)oxy)-8-(furan-2-yl)oct-5-enoate→isopropyl (Z)-8-(furan-2-yl)-8-hydroxyoct-5-enoate→isopropyl (Z)-7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)hept-5-enoate→isopropyl (R,Z)-7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)hept-5-enoate→isopropyl (R,Z)-7-(3-((tert-butyldimethylsilyl)oxy)-5-oxocyclopent-1-en-1-yl)hept-5-enoate→(S,E)-tert-butyldimethyl((5-phenyl-1-(tributylstannyl)pent-1-en-3-yl)oxy)silane→isopropyl (Z)-7-((1R,2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoate→isopropyl (Z)-7-((1R,2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpent-1-en-1-yl)-5-hydroxycyclopentyl)hept-5-enoate→isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate→3-phenylpropanal→ethynylmagnesium bromide→5-phenylpent-1-yn-3-ol→(S)-5-phenylpent-1-yn-3-ol→(S,E)-5-phenyl-1-(tributylstannyl)pent-1-en-3-ol
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