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CAS 64982-34-9
(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate
Codes: BIMA-043
Application context (from source-drug indications)
Ocular hypertensionBimatoprost/Timolol MaleateOpen-angle glaucomaBimatoprost/Timolol MaleateGlaucomaBimatoprost/Timolol MaleateOcular hypertensionBimatoprostGlaucomaBimatoprost少毛症BimatoprostOpen-angle glaucomaBimatoprost白内障Bimatoprost瘢痕Bimatoprost
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Bimatoprost/Timolol Maleate | Tier C — Watch / trade | - |
| Bimatoprost | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
dimethyl (2-oxo-4-phenylbutyl)phosphonate→(4-carboxybutyl)triphenylphosphonium bromide→methyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate→(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-hydroxyhexahydro-2H-cyclopenta[b]furan-5-yl benzoate→(Z)-7-((1R,2S,3R,5S)-3-(benzoyloxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxycyclopentyl)hept-5-enoic acid→(1R,2S,3R,4S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxy-3-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentyl benzoate→(1S,3R,4S,5R)-4-(hydroxymethyl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1S,3R,4R,5R)-4-formyl-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1R,3S,4R,5R)-4-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)-5-((E)-3-oxo-5-phenylpent-1-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1S,3R,4R,5R)-4-((E)-3-hydroxy-5-phenylpent-1-en-1-yl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→4-phenylbutan-2-one→1-bromo-4-phenylbutan-2-one→1-iodo-4-phenylbutan-2-one
dimethyl (2-oxo-4-phenylbutyl)phosphonate→(4-carboxybutyl)triphenylphosphonium bromide→methyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate→(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate→(3aR,4S,5R,6aS)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-hydroxyhexahydro-2H-cyclopenta[b]furan-5-yl benzoate→(Z)-7-((1R,2S,3R,5S)-3-(benzoyloxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxycyclopentyl)hept-5-enoic acid→(1R,2S,3R,4S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxy-3-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentyl benzoate→(1S,3R,4S,5R)-4-(hydroxymethyl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1S,3R,4R,5R)-4-formyl-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1R,3S,4R,5R)-4-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)-5-((E)-3-oxo-5-phenylpent-1-en-1-yl)cyclopentane-1,3-diyl dibenzoate→(1S,3R,4R,5R)-4-((E)-3-hydroxy-5-phenylpent-1-en-1-yl)-5-((Z)-7-isopropoxy-7-oxohept-2-en-1-yl)cyclopentane-1,3-diyl dibenzoate→4-phenylbutan-2-one→1-bromo-4-phenylbutan-2-one→1-iodo-4-phenylbutan-2-one
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