Niclosamide

Tier C — Watch / trade

Niclosamide

Bayer

Originator

1995

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：Not applicable

Brand：Yomesan, Niclocide, Tredemine

Indications (approved)：蛔虫病

Regional status

Phase III

2020-10-07

Discontinued

2015-08-01

China

Approved

1995-01-01

Japan

Synthetic routes & intermediates3 routes

Originator routes × 0Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 2 · Total yield /

(I)277894-1-a100-01-6(II)277894-1-a121-87-9(III)277894-1-a321-14-2API · Niclosamide

Code	CAS No.	Intermediate
(I)277894-1-a	100-01-6 Available	1-Amino-4-nitrobenzene
(II)277894-1-a	121-87-9	1-Amino-2-chloro-4-nitrobenzene
(III)277894-1-a	321-14-2	5-Chloro-2-hydroxybenzoic acid

OptimisedRoute 2Steps 1 · Total yield /

(I)277894-2-a6626-92-2API · Niclosamide

Code	CAS No.	Intermediate
(I)277894-2-a	6626-92-2	5-Chloro-N-(2-chlorophenyl)-2-hydroxybenzamide

OptimisedRoute 3Steps 2 · Total yield /

(I)277894-3-a321-14-2(II)277894-3-a—(III)277894-3-a121-87-9API · Niclosamide

Code	CAS No.	Intermediate
(I)277894-3-a	321-14-2	5-Chloro-2-hydroxybenzoic acid
(II)277894-3-a	-	(5-Chloro-2-hydroxyphenyl)(1H-imidazol-1-yl)methanone
(III)277894-3-a	121-87-9	1-Amino-2-chloro-4-nitrobenzene

Frequently asked questions

What are the approved indications of Niclosamide?

Approved indications include: 蛔虫病.

When does the Niclosamide patent expire?

No public expiry year is available for Niclosamide yet; this page updates once verified.

How many synthesis routes are recorded for Niclosamide?

3 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Niclosamide intermediates?

1 intermediate CAS of Niclosamide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Niclosamide intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-04