Tolcapone
Tier C — Watch / tradeTolcapone
Targets：COMT
Brand：Tasmar
Indications (approved)：Parkinson's disease
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| TOLC-001 | 2426-87-1 | 4-(benzyloxy)-3-methoxybenzaldehyde |
| TOLC-002 | 106-38-7 | 1-bromo-4-methylbenzene |
| TOLC-003 | 134612-19-4 | (4-(benzyloxy)-3-methoxyphenyl)(p-tolyl)methanol |
| TOLC-004 | 134612-29-6 | (4-(benzyloxy)-3-methoxyphenyl)(p-tolyl)methanone |
| TOLC-005 | 134612-39-8 | (4-hydroxy-3-methoxyphenyl)(p-tolyl)methanone |
| TOLC-006 | 134612-80-9 | (4-hydroxy-3-methoxy-5-nitrophenyl)(p-tolyl)methanone |
| Code | CAS No. | Intermediate |
|---|---|---|
| TOLC-007 | 84211-30-3 | 3,4-dihydroxy-5-nitrobenzoic acid |
| TOLC-008 | 119735-14-7 | 3,4-dihydroxy-5-nitrobenzoyl chloride |
Frequently asked questions
What are the approved indications of Tolcapone?
Approved indications include: Parkinson's disease.
When does the Tolcapone patent expire?
No public expiry year is available for Tolcapone yet; this page updates once verified.
How many synthesis routes are recorded for Tolcapone?
2 synthesis routes are recorded; the shortest is 2 steps with 25.8 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Tolcapone intermediates?
All intermediates in Tolcapone routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Tolcapone intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-04