Isoniazid

Tier C — Watch / trade

Isoniazid

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：Not applicable

Brand：Rimifon

Indications (approved)：Pulmonary tuberculosis

Regional status

Phase I

2018-06-12

Approved

China

Approved

1984-01-01

Japan

Approved

1952-07-01

Synthetic routes & intermediates4 routes

Originator routes × 0Optimised (non-patent) × 3Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 2Steps 3 · Total yield /

Isoniazid-013100-48-1Isoniazid-0141453-82-3API · Isoniazid

Code	CAS No.	Intermediate
Isoniazid-013	100-48-1	4-Pyridinenitrile
Isoniazid-014	1453-82-3	Isonicotinamide

OptimisedRoute 3Steps 2 · Total yield 125.2(Isoniazid (Free))

Isoniazid-0081570-45-2Isoniazid-0141453-82-3Isoniazid-0155341-61-7Isoniazid-0127803-57-8,10217-52-4Isoniazid-0165921-54-0API · Isoniazid

Code	CAS No.	Intermediate
Isoniazid-008	1570-45-2	Ethyl isonicotinate
Isoniazid-014	1453-82-3	Isonicotinamide
Isoniazid-015	5341-61-7	Hydrazine dihydrochloride
Isoniazid-012	7803-57-8,10217-52-4	Hydrazine hydrate
Isoniazid-016	5921-54-0	2-Butanone, azine

OptimisedRoute 4Steps 3 · Total yield /

Isoniazid-01715854-87-2Isoniazid-0181220040-66-3Isoniazid-0127803-57-8,10217-52-4Isoniazid-019—Isoniazid-0201220040-67-4API · Isoniazid

Code	CAS No.	Intermediate
Isoniazid-017	15854-87-2	4-Iodopyridine
Isoniazid-018	1220040-66-3	Pyridine-4-[11C]carbonitrile
Isoniazid-012	7803-57-8,10217-52-4	Hydrazine hydrate
Isoniazid-019	-	Pyridine-4-[11C]carboximidohydrazide
Isoniazid-020	1220040-67-4	Pyridine-4-[11C]carbohydrazide

ProcessRoute 1Steps 9 · Total yield 1812.364g(Isoniazid (Free))

Isoniazid-00177-92-9Isoniazid-00253798-96-2Isoniazid-003—Isoniazid-00499-11-6Isoniazid-0055398-44-7Isoniazid-00655-22-1Isoniazid-007108-89-4Isoniazid-0081570-45-2Isoniazid-0092459-09-8Isoniazid-01052248-99-4Isoniazid-011—Isoniazid-0127803-57-8,10217-52-4API · Isoniazid

Code	CAS No.	Intermediate
Isoniazid-001	77-92-9	2-Hydroxypropane-1,2,3-tricarboxylic acid
Isoniazid-002	53798-96-2	2-Hydroxy-4-methoxy-2-(2-methoxy-2-oxoethyl)-4-oxobutanoic acid
Isoniazid-003	-	2,6-Dihydroxyisonicotinate
Isoniazid-004	99-11-6	2,6-Dihydroxyisonicotinic acid
Isoniazid-005	5398-44-7	2,6-Dichloropyridine-4-carboxylic acid
Isoniazid-006	55-22-1	4-Picolinic acid
Isoniazid-007	108-89-4 Available	4-Methylpyridine
Isoniazid-008	1570-45-2	Ethyl isonicotinate
Isoniazid-009	2459-09-8	4-Methoxycarbonylpyridine
Isoniazid-010	52248-99-4	Butyl isonicotinate
Isoniazid-011	-	Propyl isonicotinate
Isoniazid-012	7803-57-8,10217-52-4	Hydrazine hydrate

Frequently asked questions

What are the approved indications of Isoniazid?

Approved indications include: Pulmonary tuberculosis.

When does the Isoniazid patent expire?

No public expiry year is available for Isoniazid yet; this page updates once verified.

How many synthesis routes are recorded for Isoniazid?

4 synthesis routes are recorded; the shortest is 2 steps with 125.2(Isoniazid (Free)) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Isoniazid intermediates?

1 intermediate CAS of Isoniazid are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Isoniazid intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-04