Metacavir

Tier C — Watch / trade

Metacavir

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：RT, HBV pol

Indications (approved)：Chronic hepatitis B, Hepatitis B

Regional status

China

Phase II

2012-12-01

Japan

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 231 mg

Metacavir—METACA-001118-00-3METACA-002—METACA-003—METACA-00485326-06-3METACA-005858934-85-7METACA-0061630991-03-5API · Metacavir

Code	CAS No.	Intermediate
Metacavir	-	((2S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol
METACA-001	118-00-3	2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
METACA-002	-	tert-butyl (9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)carbamate
METACA-003	-	tert-butyl (9-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)carbamate
METACA-004	85326-06-3	2-amino-9-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
METACA-005	858934-85-7	((2S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetate
METACA-006	1630991-03-5	((2S,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetate

Frequently asked questions

What are the approved indications of Metacavir?

Approved indications include: Chronic hepatitis B, Hepatitis B.

When does the Metacavir patent expire?

No public expiry year is available for Metacavir yet; this page updates once verified.

How many synthesis routes are recorded for Metacavir?

1 synthesis routes are recorded; the shortest is 6 steps with 231 mg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Metacavir intermediates?

All intermediates in Metacavir routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Metacavir intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-13