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CAS 85326-06-3
2-amino-9-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
Codes: METACA-004
Application context (from source-drug indications)
Chronic hepatitis BMetacavirHepatitis BMetacavir
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Metacavir | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
((2S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol→2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one→tert-butyl (9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)carbamate→tert-butyl (9-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)carbamate→2-amino-9-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one→((2S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetate→((2S,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetate
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