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Serlopitant
Tier C — Watch / tradeSerlopitant
Menlo Therapeutics Inc
Originator
-
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：NK1R
Indications (approved)：大疱性表皮松解症
Regional status
US
Phase II
2019-04-18
EU
-
China
-
Japan
-
Synthetic routes & intermediates2 routes
Originator routes × 1Optimised (non-patent) × 0Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 12 · Total yield 0.49 g
SERL-001405-50-5SERL-002457948-95-7SERL-003860642-35-9SERL-004860642-36-0SERL-005623-91-6SERL-006—SERL-007860642-62-2SERL-008860642-64-4SERL-009912807-27-3SERL-010860642-65-5SERL-011860642-66-6SERL-012—SERL-013860642-67-7SERL-014860642-68-8SERL-0153859-41-4API · Serlopitant
| Code | CAS No. | Intermediate |
|---|---|---|
| SERL-001 | 405-50-5 | 2-(4-fluorophenyl)acetic acid |
| SERL-002 | 457948-95-7 | 2-(4-fluorophenyl)-N-methoxy-N-methylacetamide |
| SERL-003 | 860642-35-9 | 1-(4-fluorophenyl)but-3-en-2-one |
| SERL-004 | 860642-36-0 | (Z)-tert-butyl((1-(4-fluorophenyl)buta-1,3-dien-2-yl)oxy)dimethylsilane |
| SERL-005 | 623-91-6 | diethyl fumarate |
| SERL-006 | - | (1R,2S,3S)-diethyl 6-((tert-butyldimethylsilyl)oxy)-4'-fluoro-1,2,3,4-tetrahydro-[1,1'-biphenyl]-2,3-dicarboxylate |
| SERL-007 | 860642-62-2 | (1S,2S,3R)-diethyl 3-(4-fluorophenyl)-4-oxocyclohexane-1,2-dicarboxylate |
| SERL-008 | 860642-64-4 | (1S,2S,3R,4S)-diethyl 3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-dicarboxylate |
| SERL-009 | 912807-27-3 | ((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate) |
| SERL-010 | 860642-65-5 | (1S,2S,3R,4S)-diethyl 4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-dicarboxylate |
| SERL-011 | 860642-66-6 | ((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)dimethanol |
| SERL-012 | - | ((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate |
| SERL-013 | 860642-67-7 | (3aR,4R,5S,7aS)-2-benzyl-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole |
| SERL-014 | 860642-68-8 | (3aR,4R,5S,7aS)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole |
| SERL-015 | 3859-41-4 | cyclopentane-1,3-dione |
ProcessRoute 2Steps 12 · Total yield 7.45 kg
SERL-01734675-24-6SERL-018920025-40-7SERL-019920025-41-8SERL-020—SERL-021920025-43-0SERL-022920025-44-1SERL-023920025-45-2SERL-024920025-42-9SERL-025920025-47-4SERL-001405-50-5SERL-002457948-95-7SERL-003860642-35-9SERL-009912807-27-3SERL-016920025-39-4API · Serlopitant
| Code | CAS No. | Intermediate |
|---|---|---|
| SERL-017 | 34675-24-6 | bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) fumarate |
| SERL-018 | 920025-40-7 | (1R,2S,3S)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 4'-fluoro-6-((triethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-2,3-dicarboxylate |
| SERL-019 | 920025-41-8 | (1S,2S,3R)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-(4-fluorophenyl)-4-oxocyclohexane-1,2-dicarboxylate |
| SERL-020 | - | (1S,2S,3R,4S)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-dicarboxylate |
| SERL-021 | 920025-43-0 | ((1S,2R,3R,4S)-3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-diyl)dimethanol |
| SERL-022 | 920025-44-1 | ((1S,2R,3R,4S)-3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate) |
| SERL-023 | 920025-45-2 | ((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate) |
| SERL-024 | 920025-42-9 | (3aR,4R,5S,7aS)-2-allyl-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole |
| SERL-025 | 920025-47-4 | (3aR,4R,5S,7aS)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole acetate |
| SERL-001 | 405-50-5 | 2-(4-fluorophenyl)acetic acid |
| SERL-002 | 457948-95-7 | 2-(4-fluorophenyl)-N-methoxy-N-methylacetamide |
| SERL-003 | 860642-35-9 | 1-(4-fluorophenyl)but-3-en-2-one |
| SERL-009 | 912807-27-3 | ((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate) |
| SERL-016 | 920025-39-4 | (Z)-triethyl((1-(4-fluorophenyl)buta-1,3-dien-2-yl)oxy)silane |
Frequently asked questions
What are the approved indications of Serlopitant?
Approved indications include: 大疱性表皮松解症.
When does the Serlopitant patent expire?
No public expiry year is available for Serlopitant yet; this page updates once verified.
How many synthesis routes are recorded for Serlopitant?
2 synthesis routes are recorded; the shortest is 12 steps with 0.49 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Serlopitant intermediates?
All intermediates in Serlopitant routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Serlopitant intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-08