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CAS 920025-40-7
(1R,2S,3S)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 4'-fluoro-6-((triethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-2,3-dicarboxylate
Codes: SERL-018
Application context (from source-drug indications)
大疱性表皮松解症Serlopitant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Serlopitant | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) fumarate→(1R,2S,3S)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 4'-fluoro-6-((triethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-2,3-dicarboxylate→(1S,2S,3R)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-(4-fluorophenyl)-4-oxocyclohexane-1,2-dicarboxylate→(1S,2S,3R,4S)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-dicarboxylate→((1S,2R,3R,4S)-3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-diyl)dimethanol→((1S,2R,3R,4S)-3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate)→((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate)→(3aR,4R,5S,7aS)-2-allyl-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole→(3aR,4R,5S,7aS)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole acetate→2-(4-fluorophenyl)acetic acid→2-(4-fluorophenyl)-N-methoxy-N-methylacetamide→1-(4-fluorophenyl)but-3-en-2-one→((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate)→(Z)-triethyl((1-(4-fluorophenyl)buta-1,3-dien-2-yl)oxy)silane
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