Zatolmilast
Tier C — Watch / tradeZatolmilast
Targets：PDE4
Indications (approved)：脆性X染色体综合征, 乔丹综合征, Hepatic function decline, Renal impairment, Alzheimer's disease, Depression
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| BPN-14770-001 | 766-84-7 | 3-chlorobenzonitrile |
| BPN-14770-002 | 60612-87-5 | ethyl 3-chlorobenzimidate hydrochloride |
| BPN-14770-003 | 25412-62-8 | 3-chlorobenzimidamide |
| BPN-14770-004 | 372-31-6 | ethyl 4,4,4-trifluoro-3-oxobutanoate |
| BPN-14770-005 | 1281566-89-9 | 2-(3-chlorophenyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one |
| BPN-14770-006 | 1443978-20-8 | 4-chloro-2-(3-chlorophenyl)-6-(trifluoromethyl)pyrimidine |
| BPN-14770-007 | 6633-76-7 | 2-(4-aminophenyl)acetamide |
| BPN-14770 | 1606975-12-5 | - |
Frequently asked questions
What are the approved indications of Zatolmilast?
Approved indications include: 脆性X染色体综合征, 乔丹综合征, Hepatic function decline, Renal impairment, Alzheimer's disease, Depression.
When does the Zatolmilast patent expire?
No public expiry year is available for Zatolmilast yet; this page updates once verified.
How many synthesis routes are recorded for Zatolmilast?
1 synthesis routes are recorded; the shortest is 5 steps with 0.042 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Zatolmilast intermediates?
All intermediates in Zatolmilast routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Zatolmilast intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-05