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CAS 1219707-38-6
(R)-3-(4-(5,6-dihydro-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
Codes: DELPA-013
Application context (from source-drug indications)
Non-tuberculous mycobacterial infectionDelpazolidPulmonary tuberculosisDelpazolidMycobacterium tuberculosis infectionDelpazolidStaphylococcal infectionDelpazolid
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Delpazolid | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,2-difluoro-4-nitrobenzene→2-((2-fluoro-4-nitrophenyl)amino)ethan-1-ol→tert-butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)(2-fluoro-4-nitrophenyl)carbamate→tert-butyl (4-amino-2-fluorophenyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate→tert-butyl (4-(((benzyloxy)carbonyl)amino)-2-fluorophenyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate→(R)-oxiran-2-ylmethyl pivalate→tert-butyl (R)-(2-((tert-butyldimethylsilyl)oxy)ethyl)(2-fluoro-4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)carbamate→(R)-(3-(4-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl benzoate→(R)-(3-(3-fluoro-4-((2-hydroxyethyl)amino)phenyl)-2-oxooxazolidin-5-yl)methyl benzoate→(R)-(3-(3-fluoro-4-((2-((methylsulfonyl)oxy)ethyl)amino)phenyl)-2-oxooxazolidin-5-yl)methyl benzoate→(R)-(3-(3-fluoro-4-((2-hydrazineylethyl)amino)phenyl)-2-oxooxazolidin-5-yl)methyl benzoate→(R)-4-(2-fluoro-4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)-5,6-dihydro-1,2,4-triazine-1(4H)-carbaldehyde→(R)-3-(4-(5,6-dihydro-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one
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