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CAS 157925-17-2
ethyl (R,Z)-1-(4-(3-methyl-5-oxothiophen-2(5H)-ylidene)-4-(3-methylthiophen-2-yl)butyl)piperidine-3-carboxylate
Codes: TIAG-017
Application context (from source-drug indications)
EpilepsyTiagabine HydrochlorideSeizureTiagabine HydrochlorideAnxiety disorderTiagabine HydrochlorideObstructive sleep apnoea syndromeTiagabine HydrochlorideCocaine addictionTiagabine Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tiagabine Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-bromo-5-chloro-3-methylthiophene→(5-chloro-3-methylthiophen-2-yl)(3-methylthiophen-2-yl)methanol→(5-chloro-3-methylthiophen-2-yl)(3-methylthiophen-2-yl)methanone→(5-methoxy-3-methylthiophen-2-yl)(3-methylthiophen-2-yl)methanone→cyclopropyl(5-methoxy-3-methylthiophen-2-yl)(3-methylthiophen-2-yl)methanol→(Z)-5-(4-bromo-1-(3-methylthiophen-2-yl)butylidene)-4-methylthiophen-2(5H)-one→ethyl (R,Z)-1-(4-(3-methyl-5-oxothiophen-2(5H)-ylidene)-4-(3-methylthiophen-2-yl)butyl)piperidine-3-carboxylate→3-methylthiophene-2-carbaldehyde→bromocyclopropane→ethyl (R)-piperidine-3-carboxylate
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